Exposure to protracted low-dose ionizing radiation and incident dementia in a cohort of Ontario nuclear power plant workers.

Objectives: Emerging evidence suggests that low-dose ionizing radiation increases the risk of neurodegenerative diseases. Past studies have relied on death data to identify dementia, and these are prone to under-ascertainment and complicate the estimation of health risks as individuals tend to live with dementia for many years following onset. We present findings from the first occupational cohort to investigate dementia risk from low-dose radiation using incident outcomes.

Prenatal exposure to fine particulate matter composition and risk of cerebral palsy: A population-based retrospective cohort study in Ontario, Canada.

Background: Existing literature suggests an association between prenatal exposure to fine particulate air pollution (PM) and cerebral palsy (CP). However, the impact of individual PM components (SO, NH, NO, SS, BC, dust, OM) on CP risk remains unknown.

Objective: To examine the associations between prenatal exposure to PM components, and risk of CP among term births in Ontario, Canada.

Associations of prenatal exposure to residential greenspace and active living environments with cerebral palsy: A population-based cohort study in Ontario, Canada.

Background: Prenatal exposure to environmental factors, such as greenspace and active living environments, has been associated with numerous health benefits, including improved neurodevelopmental outcomes. Although cerebral palsy (CP) is not typically linked to these exposures, emerging evidence suggests that exposure to environmental factors during pregnancy may influence brain development, making it important to explore their potential role in CP risk.

Methods: We conducted a retrospective cohort study using health administrative data from Ontario, Canada, between 1 April 2002 and 31 December 2020.

A population-based cohort study defined estimated glomerular filtration rate decline and kidney failure among Canadian immigrants.

The link between immigrant status, a key social determinant of health, and kidney disease remains uncertain. To evaluate this, we compared incident adverse kidney outcomes between immigrants and non-immigrants using Canadian provincial health administrative data. We conducted a population-based observational cohort study of all adult Ontario residents (immigrants and non-immigrants) with normal baseline kidney function (estimated glomerular filtration rate (eGFR) 70 mL/min/1.

Incident chronic kidney disease among Canadian immigrants: a population-based cohort study.

Introduction: A 'healthy immigrant effect' has been demonstrated for a number of chronic health conditions including cardiovascular disease, diabetes mellitus and dementia; however, the link between immigrant status and kidney health remains uncertain. We sought to compare the risk for incident chronic kidney disease (CKD) between Canadian immigrants and non-immigrants.

Methods: We conducted a population-level, observational cohort study of all adult (≥18 years of age) Ontario residents, including foreign-born immigrant Canadian citizens and non-immigrant Canadian citizens by birth, with normal baseline kidney function (outpatient estimated glomerular filtration rate (eGFR) ≥70 mL/min/1.