Predicting Recurrence of Blood Blister-Like Aneurysms: The Importance of Aneurysmal Neck Area.

Background: Blood blister-like aneurysms (BBAs) are distinct aneurysms that mostly develop as small, wide-based structures at the supraclinoid segment of the internal carotid artery, often leading to subarachnoid hemorrhage and causing diagnostic and therapeutic challenges. This study aimed to identify the diagnostic indicators associated with postoperative recurrence of BBAs.

Methods: We retrospectively evaluated the clinical history, angiographic features, three-dimensional parameters, treatment methods, and outcomes of 23 patients with BBA treated at our center.

Self-limited familial focal epilepsy caused by ANK2 variants: A potentially under-recognized condition.

The Ankyrin 2 (ANK2) gene encodes the ankyrin-B protein (ANKB), which is involved in the organization and stability of membrane ion channels, transporters, and receptors in cardiomyocytes and neurons. Variants in ANK2 genes are initially reported in long QT syndrome and autism. Animal models with ANK2 deletion have exhibited seizures and been anecdotally associated with epilepsy in case reports.

Exercise Test for Patients with Long QT Syndrome.

Congenital long QT syndrome (LQTS) causes life-threatening cardiac arrhythmias and is the leading cause of sudden cardiac death in young people. Measurements of QT prolongation during exercise or postural change have been recommended to assist in the diagnosis of LQTS, particularly in those with hidden phenotypes. However, most evidence has come from single-center studies without external validation in an independent cohort.