Publications by authors named "Chen-Jun Xie"
UGT1A6 in pancreatic cancer: a promising prognostic biomarker and therapeutic target.
Clin Transl Oncol
June 2025
Objective: This study aimed to explore the role of the UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), in pancreatic cancer, focusing on its expression patterns, clinical significance, impact on tumor progression, and potential involvement in immune evasion.
Methods: UGT1A6 expression across multiple cancer types was analyzed using TNMplot, GEPIA, and The Cancer Genome Atlas (TCGA) databases. Functional experiments, including western blotting, qRT-PCR, CCK-8, and Transwell assays, were performed on pancreatic cancer cell lines to assess their proliferation and migration capabilities.
Article Synopsis
- This study investigates the impact of CDKN2A mutations (MUT) and deletions (DEL) on patient survival and response to immune checkpoint inhibitors (ICIs) across various cancer types, focusing specifically on gastric cancer.
- Data was gathered from 45,000 tumor patients across 33 cancer types, analyzing clinical outcomes and genomic factors relevant to ICI response.
- Results indicate mixed survival outcomes for CDKN2A-MUT patients depending on the cohort, with correlations between CDKN2A alterations and lower survival rates as well as varying responses to ICIs, particularly highlighting poorer outcomes in certain types of gastric cancer.