Voxel-level Radiomics and Deep Learning Based on MRI for Predicting Microsatellite Instability in Endometrial Carcinoma: A Two-center Study.

Rationale And Objectives: To develop and validate a non-invasive deep learning model that integrates voxel-level radiomics with multi-sequence MRI to predict microsatellite instability (MSI) status in patients with endometrial carcinoma (EC).

Methods: This two-center retrospective study included 375 patients with pathologically confirmed EC from two medical centers. Patients underwent preoperative multiparametric MRI (T2WI, DWI, CE-T1WI), and MSI status was determined by immunohistochemistry.