Publications by authors named "Chen-Hao Gao"
It is well-documented that early recurrence of hepatocellular carcinoma following liver transplantation can markedly impact patient survival. Accurately identifying patients at risk for early recurrence, followed by timely interventions, could greatly improve the long-term efficacy of liver transplantation. The Milan criteria, the clinical gold standard for selecting patients with a low risk of post-transplant recurrence, fails to exclude high-risk patients with biologically aggressive hepatocellular carcinoma.
View Article and Find Full Text PDFBackground: Elevated preoperative γ-glutamyl transferase (GGT) levels or reduced serum albumin levels have been established as negative prognostic factors for patients with hepatocellular carcinoma (HCC) and various other tumors. Nonetheless, the prognostic significance of the GGT to serum albumin ratio (GAR) in liver transplantation (LT) therapy for HCC is still not well-defined.
Methods: A retrospective analysis was conducted on the clinical data of 141 HCC patients who underwent LT at Shulan (Hangzhou) Hospital from June 2017 to November 2020.
Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era.
Acta Pharmacol Sin
December 2023
Article Synopsis
- SARS-CoV-2 infects not just the lungs but also the heart and blood vessels, leading to systemic inflammation and severe complications, especially in individuals with pre-existing cardiovascular diseases (CVD).
- The ongoing threat of COVID-19, including long-COVID and its variants, suggests it will drastically impact health-related risks and disease management for years to come.
- There is an urgent need to shift towards precision medicine that offers a holistic understanding of CVD in the context of COVID-19, combining medical knowledge with a new disease taxonomy to improve diagnosis, treatment, and prevention.
Immunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence. However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective method for delaying macrophage senescence is currently available. The results of this study reveal that D-galactose (D-gal) can promote J774A.
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