promotes proliferation and invasion in colorectal cancer and epithelial-mesenchymal transition.

Background: The current study aimed to investigate the effect of on the biological function of colorectal cancer (CRC) cells and its mechanism.

Methods: First, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was employed for detecting the expression of , , and in surgically resected specimens from hospitalized CRC patients, CRC-adjacent normal tissues (Normal group), human normal colon epithelial cells (FHC group), and CRC cell lines (HCT116, HT29, SW480, SW620). The cell proliferation, viability, and invasion were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), colony formation assay, transwell assay in HCT116 and SW480 cells with overexpression or inhibition of .

Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma.

Sirt family has been reported playing a significant role in the cancer development, especial its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating tumor epithelial-mesenchymal transition (EMT) and metastasis in colon cancer has not been explored. Here, the mass spectrometry and co-immunoprecipitation assays were utilized to detect that SIRT6 was physically associated with transcription factor snail. Most important, HCT116 cells transfected with SIRT6 shRNA reversed EMT, while increased the expression of TET1, and the HCT116 cells transfected with SIRT6 displayed the contrary tendency.

Changes in patients' symptoms and gastric emptying after Helicobacter pylori treatment.

Aim: To investigate the changes in clinical symptoms and gastric emptying and their association in functional dyspepsia (FD) patients.

Methods: Seventy FD patients were enrolled and divided into 2 groups Helicobacter pylori (H. pylori)-negative group (28 patients), and H.

Altering trend of clinical characteristics of colorectal cancer: a report of 3,607 cases.

Background And Objective: Incidence of colorectal cancer in China has increased since 1980s. The epidemiologic character of colorectal cancer in China is similar to that in high prevalence districts. The distributions among different regions are different, with high incidence in the Eastern coastal regions and low incidence in the Western inland.