Publications by authors named "Chandra-Jit Yadav"
The expanding worldwide population has increased the meat demand, prompting efforts to find alternatives. A promising approach is the cultivation of animal cells on edible biomaterials for cultured meat production. However, those biomaterials face challenges in their mechanical properties, cytotoxicity, and ability to support optimal cell growth.
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- Bioengineered livers are being studied as alternatives to traditional liver transplants, addressing donor shortages, but they face issues like thrombosis due to incomplete endothelial layers.
- This study focuses on applying heparin to decellularized liver scaffolds to improve blood compatibility, cell adhesion, and new blood vessel formation.
- Results showed that heparin not only reduced blood clotting and increased cell attachment but also significantly enhanced the growth of blood vessels in the scaffolds when tested in mice.
Natural scaffolds have been the cornerstone of tissue engineering for decades, providing ideal environments for cell growth within extracellular matrices. Previous studies have favored animal-derived materials, including collagen, gelatin, and laminin, owing to their superior effects in promoting cell attachment, proliferation, and differentiation compared to non-animal scaffolds, and used immortalized cell lines. However, for cultured meat production, non-animal-derived scaffolds with edible cells are preferred.
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