Influences of early sexual trauma on brain structural connectome in panic disorder and their relationship with short- and long-term treatment responses.

Background: Early traumatic experiences, particularly early sexual trauma (EST), are associated with panic disorder (PD). Using connectome-based analyses of diffusion tensor imaging, we examined the effects of EST on the brain structural networks and the associations with symptom severity and short- and long-term treatment responses in patients with PD compared to healthy controls (HCs).

Methods: 188 participants (82 PD patients and 106 HCs) were enrolled.

Comparison of cortical gyrification patterns in patients with panic disorder with and without comorbid generalized anxiety disorder.

Background: Lower functioning and higher symptom severity are observed when panic disorder (PD) co-occurs with generalized anxiety disorder (PD + GAD). No research on cortical gyrification patterns in the PD + GAD group has been conducted to date, which could show the alterations in brain connectivity in the extended fear network (EFN). This study aimed to investigate the characteristics of cortical gyrification in the PD + GAD group, compared to that in the PD without comorbid GAD (PD-GAD) group.

Self-compassion is associated with the superior longitudinal fasciculus in the mirroring network in healthy individuals.

Self-compassion (SC) involves taking an emotionally positive attitude towards oneself when suffering. Although SC has positive effects on mental well-being as well as a protective role in preventing symptoms in healthy individuals, few studies on white matter (WM) microstructures in neuroimaging studies of SC has been studied. Brain imaging data were acquired from 71 healthy participants.

Initial white matter connectivity differences between remitters and non-remitters of patients with panic disorder after 6 months of pharmacotherapy.

Panic disorder (PD) is a harmful mental condition that causes relapsed and persistent impairment. In the treatment of PD, the prognosis for PD should be considered. However, the relationship between pharmacotherapy and biomarkers, for predicting a better response through neuroimaging, is a little known.