Tissue Eosinophil Counts: A Promising Marker for Optimizing Omalizumab Treatment in Bullous Pemphigoid.

Bullous pemphigoid (BP) is the most common autoimmune blistering disease, predominantly affecting the elderly. Current treatments rely mainly on corticosteroids and immunosuppressive agents but are often limited by significant side effects. Omalizumab, an anti-IgE monoclonal antibody, has emerged as a promising off-label therapy for BP, but predictive markers for treatment response remain poorly understood.

The impact of intravenous immunoglobulin on kidney functions and thromboembolic events in dermatology patients.

Although intravenous immunoglobulin (IVIG) treatment is generally well tolerated, some adverse effects, ranging from mild to severe, can occur. Nephrotoxicity and thromboembolism are the significant adverse effects of IVIG. However, data on the frequency of thromboembolism and the impact of continuous treatment on renal functions in dermatology patients is limited.

Diagnostic Performance of Dermoscopy for Distinguishing Early Melanomas and Intermediate Melanocytic Lesions From Low-Grade Dysplastic Nevi.

Background: Early melanomas, dysplastic melanocytic nevi, and melanocytic tumours of uncertain malignant potential (MELTUMPs) reveal similar clinic and dermoscopic findings leading to underdiagnosis of malign lesions or unnecessary excision of benign ones. High-grade dysplastic nevi and MELTUMPs in the intermediate category should be recognized and completely excised.

Objectives: We evaluated the diagnostic performance of pattern analysis, ABCD rule, colour, architecture, symmetry, and homogeneity algorithm, melanoma-specific structures and asymmetry of dermoscopic features in distinguishing early melanomas, high-grade dysplastic nevi, and MELTUMPs from low-grade dysplastic nevi.

How Does Illness Perception Affect the Quality of Life and Sun Protection Behaviors of Rosacea Patients?

Background: Previous studies have noted the link between rosacea severity and quality of life, but there is limited understanding of how disease perception impacts these aspects. Additionally, sun exposure is identified as a common trigger for rosacea flare-ups, emphasizing the importance of sun protection practices in managing the condition. This cross-sectional study aims to fill the gap in the literature by investigating the relationship between clinical severity, disease perception, quality of life, and sun protection behaviors in rosacea patients.

The Significance of Eosinophil-to-Lymphocyte Ratio in Predicting Response to Omalizumab Treatment in Patients with Bullous Pemphigoid: A Case Series.

Omalizumab, a monoclonal anti-IgE antibody, has been used off-label in a few case series of bullous pemphigoids (BPs) with rapid efficacy and high safety profile. However, there is a lack of data to select patients who would get the most therapeutic benefit from omalizumab therapy. To assess if eosinophil-to-lymphocyte ratio (ELR), total serum IgE level, and serum eosinophil percentage would be useful in predicting response to omalizumab therapy in patients with BP.

The effect of patient characteristics on illness perception and sun protection behaviors in melasma.

Background/aim: Melasma, a significant cosmetic problem, has been accepted by some authors as a photoaging illness in recent times. There is no published study evaluating the effects of the clinical and sociodemographic findings on illness perception and sun protection behaviors (SPBs) in patients with melasma.

Patients/methods: Sociodemographic data, personal characteristics, and clinical features of 150 patients with melasma were recorded in this cross-sectional study.

Piebaldism Associated with Café-au-lait Macules and Intertriginous Freckling: A Case Report and Review of the Literature.

We present 9-year-old fraternal twins from a family with piebaldism, having congenital depigmented macules and meeting the diagnostic criteria for neurofibromatosis type 1 () due to the multiple café-au-lait macules (CALMs) and intertriginous freckling at the same time. It's still a debatable issue that CALMs and intertriginous freckling may be seen in the clinical spectrum of piebaldism or these patients should be regarded as coexistence of piebaldism and . However, based on recent literature and our patients' findings, we suggest that this rare phenotypic variant of piebaldism may not need the careful clinical follow-up and molecular testing for .

Examination of the Microbial Spectrum in the Etiology of Erythema Nodosum: A Retrospective Descriptive Study.

Even though infections are the most common cause of erythema nodosum (EN), only certain microorganisms take the great interest such as streptococci in knowledge. Our aim was to examine the frequency and type of infections in EN, to determine the characteristics of patients with an infectious etiology, and to discuss the role of these microbes in EN pathology in the context of their interactions with humans. Charts of 81 patients with EN who were seen between 2003 and 2017 were retrospectively reviewed.