Publications by authors named "Celine B E Busch"
Introduction: Endoscopic duodenal mucosal resurfacing (DMR) induces mucosal regeneration through hydrothermal ablation. Studies have shown that DMR improves hyperglycaemia in patients with type 2 diabetes. The INSPIRE study (n=16) aimed to eliminate insulin by combining DMR with a glucagon-like peptide-1 receptor agonist (GLP-1RA).
View Article and Find Full Text PDFBackground And Study Aims: Histological analysis of regular duodenal biopsies to study morphologic changes after duodenal ablation for type 2 diabetes (T2D) and metabolic syndrome is hampered by variability in tissue orientation. We designed an optimized tissue acquisition protocol using duodenal cold snare resections to create tissue microarrays (TMAs) and to allow for single-cell RNA sequencing (scRNA-seq).
Patients And Methods: The open-label DIRECT study included patients undergoing an upper gastrointestinal interventional endoscopy for non-duodenal indications.
Article Synopsis
- * The study included 14 patients on insulin, where ReCET was performed with optimized electroporation doses, and patients were switched to a glucagon-like peptide 1 receptor agonist afterwards.
- * Results indicated that ReCET was safe and effective, with 86% of patients remaining off insulin after 12 months and showing significant improvements in their blood sugar levels.
Role of the Intestine and Its Gut Microbiota in Metabolic Syndrome and Obesity.
Am J Gastroenterol
June 2024
Article Synopsis
- The metabolic syndrome (MetSyn) is a major global health challenge, consisting of various metabolic disorders like obesity, high blood pressure, and high blood sugar, which increase cardiovascular risk.
- Recent research highlights the significance of the gut microbiome in understanding these disorders, revealing how gut microorganisms affect metabolic processes and overall health.
- This review examines the relationship between the gut microbiome and MetSyn, exploring how this connection could lead to new treatment options for metabolic disorders and obesity.
Background And Aims: The duodenum has been shown to play a key role in glucose homeostasis. Duodenal mucosal resurfacing (DMR) is an endoscopic procedure for patients with type 2 diabetes (T2D) in which the duodenal mucosa is hydrothermally ablated. DMR improves glycemic control, but the underlying mechanisms remain unclear.
View Article and Find Full Text PDFPerformance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction.
J Hepatobiliary Pancreat Sci
April 2022
Background: Acute cholangitis is an infection requiring endoscopic retrograde cholangiopancreatography (ERCP) and antibiotics. Several diagnostic tools help to diagnose cholangitis. Because diagnostic performance of these tools has not been studied and might therefore impose unnecessary ERCPs, we aimed to evaluate this.
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