Deploying ambient clinical intelligence to improve care: A research article assessing the impact of nuance DAX on documentation burden and burnout.

Introduction: Occupational burnout among clinical care providers, due in part to documentation burden, has reached crisis level. This study measured the effect of using new clinical documentation software, an 'ambient clinical intelligence' (ACI) program, to reduce the documentation workload and improve provider wellbeing.

Methods: This was a randomised, control study with a step-wedge design.

Peritumoral administration of DRibbles-pulsed antigen-presenting cells enhances the antitumor efficacy of anti-GITR and anti-PD-1 antibodies via an antigen presenting independent mechanism.

Background: TNF receptor family agonists and checkpoint blockade combination therapies lead to minimal tumor clearance of poorly immunogenic tumors. Therefore, a need to enhance the efficacy of this combination therapy arises. Antigen-presenting cells (APCs) present antigen to T cells and steer the immune response through chemokine and cytokine secretion.