Publications by authors named "Catherine Rutledge"
Chronic stress is a major risk factor for neuropsychiatric disorders, acting via increased neuroinflammation and disrupted synaptic plasticity. While non-invasive visual or audiovisual neurostimulation (AV flicker) at 40Hz has been shown to modulate brain immune signaling and improve cognitive performance in mouse models of Alzheimer's disease, its effects in the context of stress remain unknown. Here we show that AV flicker protects against stress-induced behavioral, microglial, astrocytic, and synaptic changes in a sex- and frequency-specific manner.
View Article and Find Full Text PDFThe accumulation of mutant huntingtin protein aggregates in neurons is a pathological hallmark of Huntington's disease (HD). The glymphatic system, a brain-wide perivascular network, facilitates the exchange of interstitial fluid and cerebrospinal fluid (CSF), supporting interstitial solute clearance of brain wastes. In this study, we employed dynamic glucose-enhanced (DGE) MRI to measure d-glucose clearance from CSF as a tool to predict glymphatic function in a mouse model of HD.
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- Cystic fibrosis (CF) leads to heightened rates of depression and anxiety among patients and caregivers, prompting the formation of guidelines for behavioral health screening by key organizations in 2016.
- A study was conducted within the Department of Defense (DoD) healthcare system to assess the integration of behavioral health care in routine CF treatment by surveying program leaders from six CF centers.
- The results showed that 80% of these centers are engaging in screenings for psychological distress among CF patients aged 12 and older, revealing the current state of mental health support available.