Publications by authors named "Carlos Rangel-Pelaez"
Objective: The common gain-of-function variant rs35705950, located in the promoter of gene, has been strongly associated with interstitial lung diseases (ILDs) of different aetiology, such as idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis-associated ILD (RA-ILD). In this study, we aimed to investigate the association of this variant and its nearby single nucleotide polymorphisms (SNPs) in the largest cohort of systemic sclerosis-associated ILD (SSc-ILD) to date.
Methods: Samples were collected from blood/saliva, followed by DNA extraction and genotyping using SNP arrays.
Article Synopsis
- Autoimmune rheumatic diseases (ARDs) like rheumatoid arthritis and lupus have chronic inflammation caused by a malfunctioning immune system, and many patients struggle to find effective treatments due to the persistence of autoreactive B cells.
- CAR-T cell therapy, successful in treating certain cancers, involves using genetically engineered T cells to target specific antigens, with CD19 CAR-T cells showing promise in eliminating harmful B cells and helping patients achieve clinical remission.
- The review explores the potential of CD19 CAR-T cells for treating ARDs, discussing clinical successes and important factors like target cell selection, CAR design, management of side effects, and the possibility of long-term immune restoration.