Publications by authors named "Candelaria O'Farrell"
Emergent therapies (ET), which include intravenous immunoglobulin (IVIG), corticosteroids and intravenous anti-Rho(D) immunoglobulin, are used to treat acute episodes of bleeding in children with immune thrombocytopenia (ITP). There are currently no known biomarkers or clinical features predictive of treatment response to any specific ET. Thus, the treatment of ITP remains largely trial and error, exposing patients to potentially ineffective medications, which are often expensive and associated with adverse effects.
View Article and Find Full Text PDFInvasive Candidiasis in Pediatric Hematologic Malignancy: Increased Risk of Dissemination With Candida tropicalis.
Pediatr Infect Dis J
January 2025
Article Synopsis
- Candida species are a leading cause of invasive fungal diseases, particularly affecting children with blood cancers; the study found that non-albicans Candida (NAC), especially C. tropicalis, are linked to worse outcomes in these patients.* -
- Researchers reviewed data from 53 patients over a decade and discovered a high incidence rate of invasive candidiasis (IC) and a significant link between C. tropicalis infections and dissemination to various organs, including the eyes and skin.* -
- The study highlights the importance of eye examinations in patients with IC, revealing that a notable percentage showed evidence of intraocular candidiasis, and emphasizes the need for further research to refine screening strategies for at-risk patients.*
Article Synopsis
- Researchers conducted a genome-wide association study to identify genetic variants linked to pediatric immune thrombocytopenia (ITP) in a large group of patients.
- Six significant genetic variants were found, particularly in the genes NAV2 and NKD1, which are associated with the Wnt signaling pathway and inversely correlated with ITP.
- The study highlighted that no significant genetic variants were found to differentiate between those with ITP who recovered quickly and those who developed chronic ITP, suggesting a complex genetic influence on disease outcomes.
Article Synopsis
- Crohn's disease is an inflammatory bowel disease that can affect various parts of the body, not just the gastrointestinal tract, and its symptoms can appear at different times.
- The report details a case of a 16-year-old boy who developed a stubborn rash in specific areas of the body, which turned out to be linked to Crohn's disease.
- After experiencing gastrointestinal symptoms, he was diagnosed with Crohn's disease, and his skin lesions improved after being treated with a medication called adalimumab.
Fibrinogen replacement therapy is a treatment mainstay for patients with afibrinogenemia and significant bleeding. A male infant with congenital afibrinogenemia and several spontaneous hemarthroses commenced cryoprecipitate prophylaxis but developed severe urticarial reactions. He transitioned to a human fibrinogen concentrate (HFC) (RiaSTAP , CSL Behring; 70 mg/kg biweekly) but continued experiencing hemarthroses (estimated annualized bleeding rate [ABR]: 5-6) and severe anaphylactic reactions, despite pre- and postinfusion medications.
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