Publications by authors named "Caleb Small"
In silico integrative scRNA analysis of human colonic epithelium indicates four tuft cell subtypes.
Am J Physiol Gastrointest Liver Physiol
February 2025
This study integrated and analyzed human single-cell RNA sequencing data from four publicly available datasets to enhance cellular resolution, unveiling a complex landscape of tuft cell heterogeneity within the human colon. Four tuft subtypes (TC1-TC4) emerged, as defined by unique gene expression profiles, indicating potentially novel biological functions. Tuft cell 1 (TC1) was characterized by an antimicrobial peptide signature; TC2 had an increased transcription machinery gene expression profile consistent with a progenitor-like cell; TC3 expressed genes related to ganglion (neuronal) development; and TC4 expressed genes related to tight junctions.
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- The study aimed to identify burn patients who would need intensive rehabilitation after being discharged based on their symptoms at discharge.
- Researchers analyzed data from 1,049 adult burn patients and identified three clusters: low, moderate, and high symptom burdens, with Cluster 3 showing the most severe needs.
- The BURN-OP tool was developed to accurately identify high-risk patients (Cluster 3) at the time of discharge, helping prioritize care and improve long-term health outcomes.