Changing trends in clinical characteristics and in-hospital mortality of patients with infective endocarditis over four decades.

Background: Infective endocarditis continues to be a significant concern and may be undergoing an epidemiological transition.

Methods: Were studied 1804 consecutive episodes of infective endocarditis between 1978 and 2022. The mean age was 48 ( ± 19), and 1162 (64%) patients were male.