Search for Fractionally Charged Particles in Proton-Proton Collisions at sqrt[s]=13 TeV.

A search is presented for fractionally charged particles with charges below 1e, using their small energy loss in the tracking detector as a key variable to observe a signal. The analyzed dataset corresponds to an integrated luminosity of 138  fb^{-1} of proton-proton collisions collected at sqrt[s]=13  TeV in 2016-2018 at the CERN LHC. This is the first search at the LHC for new particles with a charge between e/3 and 0.

Rapid butterfly declines across the United States during the 21st century.

Numerous declines have been documented across insect groups, and the potential consequences of insect losses are dire. Butterflies are the most surveyed insect taxa, yet analyses have been limited in geographic scale or rely on data from a single monitoring program. Using records of 12.

Screening Methods to Discover the FDA-Approved Cancer Drug Encorafenib as Optimally Selective for Metallothionein Gene Loss Ovarian Cancer.

Background/objectives: All 11 metallothionein protein-coding genes are located on human chromosome 16q13. It is unique among human genetics to have an entire pathway's genes clustered in a short chromosomal region. Since solid tumors, particularly high-grade serous ovarian cancer (HGSC), exhibit high rates of monoallelic aneuploidy, this region is commonly lost.

Autonomous medical evaluation for guideline adherence of large language models.

Autonomous Medical Evaluation for Guideline Adherence (AMEGA) is a comprehensive benchmark designed to evaluate large language models' adherence to medical guidelines across 20 diagnostic scenarios spanning 13 specialties. It includes an evaluation framework and methodology to assess models' capabilities in medical reasoning, differential diagnosis, treatment planning, and guideline adherence, using open-ended questions that mirror real-world clinical interactions. It includes 135 questions and 1337 weighted scoring elements designed to assess comprehensive medical knowledge.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .