Comparing illness perceptions in inflammatory bowel disease and irritable bowel syndrome.

Objectives: Little research has compared illness perceptions in functional and organic conditions with similar symptom profiles. Illness perceptions may be more adverse and influential in functional conditions where objective causes for symptoms cannot be found. This study investigated the illness perceptions of patients with Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD) and the effect on symptoms and symptom-specific anxiety.

Melanization immune response of Spodoptera frugiperda to an endoparasitoid Microplitispallidipes.

Spodoptera frugiperda Smith (Lepidoptera: Noctuidae) is a worldwide invasive pest. Microplitis pallidipes Szépligeti (Hymenoptera: Braconidae) is an endoparasitoid of this pest. However, the melanization immune response of this pest to M.

Decoding mesolimbic dopamine transmission in the olfactory tubercle and its contribution to methamphetamine responses through neurochemical sensing and chemogenetics.

Central dopamine (DA) innervation of the olfactory tubercle (OT) from the ventral tegmental area (VTA) plays a critical role in encoding multisensory information and generating behavioral outputs necessary for survival. However, due to anatomical restrictions and the neurochemical heterogeneity of the VTA and OT, very little is known about the functional link between mesolimbic VTA-DA transmission in the OT and its role in mediating reward and drug seeking. In this study, we integrated fast-scan cyclic voltammetry with chemogenetics to (1) characterize the effects of chemogenetic modulation (excitation and inhibition) of mesolimbic DA transmission in the OT of both anesthetized and awake-behaving wild-type rats and (2) demonstrate that inhibition of VTA-DA neurons is sufficient to suppress methamphetamine-induced DA transmission as well as its locomotor and rewarding effects.

A Deep-Learning Solution Identifies HER2 Negative Cases and Provides ER and PR Results From H&E-Stained Breast Cancer Specimens: A Blind Validation Study.

Background: PANProfiler Breast is a UKCA-marked, deep-learning image analysis tool. It provides oestrogen and progesterone receptor (ER/PR) status and identifies human epidermal growth factor receptor-2 (HER2) negativity from whole slide images (WSIs) of haematoxylin and eosin (H&E)-stained breast cancer (BC) tissue. This study blindly validated PANProfiler's prediction of ER/PR status and identification of HER2 negative status.

Adaptive neofunctionalization of ancestral CYP6SN2vB following duplication contributes to abamectin resistance in Chilo suppressalis Walker.

Abamectin serves as a key alternative for managing diamide-resistant Chilo suppressalis. However, resistance to abamectin itself presents a significant challenge to this pest control, and its genetic basis remains poorly understood. In this study, we report an increase in field resistance to abamectin in populations of C.