Can a Matched Case-Control Methodology Efficiently Estimate Functional Relationships between Knee Implant Alignment and Revision Risk? A Simulation-Based Analysis.

Background: Conventional randomized controlled trials are generally too underpowered to yield meaningful insights into the functional dependence of revision risk on surgeon-controlled implant alignment. However, matched case-control studies focused on patients undergoing revision surgery could produce such insights. We therefore asked, can we determine, through simulation, whether such matched case-control study designs could potentially produce sufficiently accurate estimates of the functional relationships between surgeon-controlled variables and aseptic revision risk to inform surgical alignment targets for total knee arthroplasty?

Methods: We evaluated the potential for a matched case-control methodology to achieve this goal using a simulation approach in which we characterized individual patients' risk of revision by Implant Life Factor (ILF) functions that reflected the effects of both surgeon-controlled and patient-specific factors.

A Scoping Review on the Development, Implementation, and Evaluation of Nurse Well-Being Initiatives in Academic Health Systems.

Background: Nursing well-being is foundational to the specialties workforce and broader healthcare industry worldwide. Despite frequent reports and descriptions of activities that support nurses' well-being, most reports describe singular activities and programs that lack science-based structures contextualized within academic healthcare systems (AHS) with validated impact.

Aims: To evaluate and synthesize the existing national and international literature on nurse well-being initiatives offered in AHS.

Aseptic loosening is associated with medial tilting and anterior translational migration of the tibial implant in mechanically aligned total knee arthroplasty.

Background: Aseptic loosening is a significant cause of implant revision in total knee arthroplasty, and radiostereometric analysis has been used to predict loosening by measuring implant migration over time relative to its position at the time of the index surgery. Studies have suggested that analyzing specific migration patterns may improve prediction of loosening, compared to using measures of the Maximum Total Point Motion alone. Therefore, the objective of this study was to determine whether patients monitored using radiostereometric analysis who experienced either aseptic loosening or revision exhibited distinctive tibial implant migration patterns.

Soil microbial legacies influence plant survival and growth in mine reclamation.

Plants alter soil biological communities, generating ecosystem legacies that affect the performance of successive plants, influencing plant community assembly and successional trajectories. Yet, our understanding of how microbe-mediated soil legacies influence plant establishment is limited for primary successional systems and forest ecosystems, particularly for ectomycorrhizal plants. In a two-phase greenhouse experiment using primary successional mine reclamation materials with or without forest soil additions, we conditioned soil with an early successional shrub with low mycorrhizal dependence (willow, ) and a later-successional ectomycorrhizal conifer (spruce,  × ).