HYHOPE: A Phase 1 Study of Deintensified Hypofractionated Radiation Therapy for Human Papillomavirus-Associated Oropharynx Cancer.

Background: Various de-escalation strategies for human papillomavirus-associated oropharynx cancers are under investigation. We have incorporated hypofractionated radiation therapy (RT) in a phase 1 study to assess the tolerability of dose and volume deintensified RT completed in 3 weeks with weekly cisplatin.

Methods And Materials: Patients with favorable oropharynx cancer, defined as T1-3, N0-2, p16 positive, and ≤10 pack-years, were enrolled using a rolling 6 design with 46.

Clinical and Biologic Characteristics and Outcomes in Young and Middle-Aged Patients With Laryngeal Cancer: A Retrospective Cohort Analysis.

Objective: To describe the clinical and biologic characteristics and outcomes of young and middle-aged (YMA; <65 years) patients according to the presence or absence of traditional risk factors for laryngeal cancer.

Study Design: Retrospective cohort analysis.

Setting: Single-institution academic medical center.

Substance use and mental health burden in head and neck and other cancer survivors: A National Health Interview Survey analysis.

Background: Tobacco dependence, alcohol abuse, depression, distress, and other adverse patient-level influences are common in head and neck cancer (HNC) survivors. Their interrelatedness and precise burden in comparison with survivors of other cancers are poorly understood.

Methods: National Health Interview Survey data from 1997 to 2016 were pooled.

High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Clinical Review.

Background: Given the rapidly evolving nature of the field, the current state of "high-risk" head and neck cutaneous squamous cell carcinoma (HNcSCC) is poorly characterized.

Methods: Narrative review of the epidemiology, diagnosis, workup, risk stratification, staging and treatment of high-risk HNcSCC.

Results: Clinical and pathologic risk factors for adverse HNcSCC outcomes are nuanced (e.

Oncologic outcomes in primary squamous cell carcinoma of the auricle: a retrospective cohort analysis.

Purpose: The prognostic significance of auricular location in cutaneous squamous cell carcinoma (cSCC) is controversial. We aimed to characterize risk factors for, and evaluate the cumulative incidence of, locoregional recurrence in a cohort of patients with primary auricular cSCC.

Methods: The study design was a single-institution retrospective cohort review from 1/2007 to 12/2016.

Cutaneous Sarcomas.

Cutaneous sarcomas represent a rare group of tumors presenting in the head and neck. In this article, we discuss specific sarcoma tumor types and their presentation, pathogenesis, histologic findings, and management recommendations. Tumors to be reviewed include dermatofibrosarcoma protuberans, atypical fibroxanthoma, pleomorphic dermal sarcoma, cutaneous leiomyosarcoma, and angiosarcoma.

Head and neck oncology during the COVID-19 pandemic: Reconsidering traditional treatment paradigms in light of new surgical and other multilevel risks.

The COVID-19 pandemic demands reassessment of head and neck oncology treatment paradigms. Head and neck cancer (HNC) patients are generally at high-risk for COVID-19 infection and severe adverse outcomes. Further, there are new, multilevel COVID-19-specific risks to patients, surgeons, health care workers (HCWs), institutions and society.

Comparison of Outcomes in Medical Therapy vs Surgical Intervention of Esophageal Foreign Bodies.

Objectives (1) Compare efficacy of primary medical therapy vs primary surgical intervention in patients with esophageal foreign bodies (EFBs). (2) Investigate variables that may predict successful outcomes in patients treated for EFBs. Study Design Case series with chart review.

Minimally Invasive Approach for Resection of Parameningeal Rhabdomyosarcoma.

 About one-third of rhabdomyosarcomas arise in the head and neck, with parameningeal primaries accounting for half of these. Principles of management involve chemotherapy, radiation, or both, in addition to surgical biopsy, debulking, and complete or near-complete resection. In the head and neck, diagnostic biopsies have historically been performed without attempt at resection due to proximity to critical structures and cosmetic considerations.

Identification of Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma.

Importance: ERBB2 (formerly HER2) is an important drug target in breast cancer, where anti-ERBB2 therapy has been shown to lead to improvements in disease recurrence and overall survival. ERBB2 status in head and neck squamous cell carcinoma (HNSCC) has not been well studied. Identification of ERBB2-positive tumors and characterization of response to ERBB2 therapy could lead to targeted treatment options in HNSCC.

Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing.

Background: Targeted sequencing of patients with epidemiologically low-risk (ELR) head and neck squamous cell carcinoma (HNSCC) could help identify novel drivers or lost suppressors leading to precision medicine protocols and improved survival rates.

Methods: A patient with ELR-HNSCC was selected for targeted sequencing. We then assessed next generation sequencing cohorts from the Oncomine Powertool Database, which contains pan-cancer data from The Cancer Genome Atlas (TCGA).

A lean neck mass clinic model: Adding value to care.

Objectives/hypothesis: To demonstrate that ultrasound-guided fine needle aspiration (USFNA) with on-site cytopathologic analysis eliminates unnecessary diagnostic testing, return visits, and repeat procedures and optimizes quality of care.

Study Design: Retrospective cohort.

Methods: Sixty-one new patients (28 female; 33 male; age range=19-85 years) were seen in our dedicated neck mass clinic over a 1-year period.

Infantile Frey's syndrome.

Frey's syndrome in children is rare and often erroneously attributed to food allergy. Here we describe a case of Frey's syndrome in an infant and provide a review of the literature. Awareness of this condition is important for the Otolaryngologist in order to avoid unnecessary medical costs and procedures and provide reassurance to both parents and primary care providers in the setting of this benign condition.