Effects of air and light pollution on brain and behavioral function: Potential synergy.

The growing global prevalence of artificial light at night (ALAN) and air pollution has raised concerns regarding their effects on human health. Several epidemiological, preclinical, and clinical studies suggest that both ALAN and air pollution can independently contribute to adverse brain health outcomes, including cognitive decline, increased risk of neurodegenerative diseases, and behavioral disorders. Air pollutants can enter the bloodstream and reach the brain, leading to potential neuropathology.

Circadian influences on central nervous system barriers and the glymphatic system.

The central nervous system (CNS), comprising the brain and spinal cord, is fortified by complex barriers that protect the underlying organs and maintain homeostasis. The importance of proper fortification and homeostatic regulation provided by these systems has broad implications for many physiological processes and several pathological conditions are associated with their disruption. Recent studies support the notion that CNS barriers and fluids are regulated by circadian rhythms.

Chronotherapeutics for Solid Tumors.

Circadian rhythms are internal manifestations of the 24-h solar day that allow for synchronization of biological and behavioral processes to the external solar day. This precise regulation of physiology and behavior improves adaptive function and survival. Chronotherapy takes advantage of circadian rhythms in physiological processes to optimize the timing of drug administration to achieve maximal therapeutic efficacy and minimize negative side effects.