Prospective, Matched Case-Control Study of Endoscopic Sleeve Gastroplasty and Semaglutide in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease at One Year.

Purpose: Endoscopic sleeve gastroplasty (ESG) and GLP-1RA are proven obesity interventions with potential to aid patients who have MASLD. However, their comparative effectiveness remains unclear. This study aimed to compare ESG and semaglutide in MASLD patients regarding weight loss and improvements in metabolic parameters, including liver enzymes, and FIB-4 scores.

The small regulatory RNA DsrA silences the locus of enterocyte effacement of enteropathogenic in an RpoS-dependent manner.

Attaching and effacing (A/E) pathogens adhere to intestinal cells (attachment) and destroy their microvilli (effacement). The A/E pathophenotype is encoded by a cluster of genes that are organized into the pathogenicity island called locus of enterocyte effacement (LEE). While transcriptional regulation of the LEE has been extensively interrogated in A/E pathogens, posttranscriptional regulation remains poorly understood.

Generative Large Language Models Trained for Detecting Errors in Radiology Reports.

Background Large language models (LLMs) offer promising solutions, yet their application in medical proofreading, particularly in detecting errors within radiology reports, remains underexplored. Purpose To develop and evaluate generative LLMs for detecting errors in radiology reports during medical proofreading. Materials and Methods In this retrospective study, a dataset was constructed with two parts.

A systematic review of machine learning-based prognostic models for acute pancreatitis: Towards improving methods and reporting quality.

Background: An accurate prognostic tool is essential to aid clinical decision-making (e.g., patient triage) and to advance personalized medicine.

A Randomized, Double-Blind, Two-Way Cross-over Study to Evaluate the Efficacy of Liraglutide Treatment in Patients Undergoing Transoral Outlet Reduction Endoscopy for Weight Regain Post Roux-en-Y Gastric Bypass.

Background: Transoral outlet reduction endoscopy (TORe) and glucagon-like peptide-1 agonist, liraglutide, have individually shown promise in managing weight regain after Roux-en-Y gastric bypass. However, combined effects of adjunctive liraglutide to TORe remain unexplored. A cross-over design was utilized to evaluate the efficacy of liraglutide treatment when initiated immediately post-TORe or 1 year post-TORe.

Critical appraisal of machine learning prognostic models for acute pancreatitis: protocol for a systematic review.

Acute pancreatitis (AP) is an acute inflammatory disorder that is common, costly, and is increasing in incidence worldwide with over 300,000 hospitalizations occurring yearly in the United States alone. As its course and outcomes vary widely, a critical knowledge gap in the field has been a lack of accurate prognostic tools to forecast AP patients' outcomes. Despite several published studies in the last three decades, the predictive performance of published prognostic models has been found to be suboptimal.

Quality and Popularity Trends of Weight Loss Procedure Videos on TikTok.

Introduction: The use of social media as a medical information tool parallels rising obesity rates. TikTok, the popular video-sharing platform, contains nearly 99,000 videos hashtagged "weightloss." Prior studies have analyzed the quality of medical information on TikTok in other areas of medicine.

The two sRNAs OmrA and OmrB indirectly repress transcription from the LEE1 promoter of enteropathogenic Escherichia coli.

Enteropathogenic Escherichia coli (EPEC) is a diarrheagenic bacterium that predominantly infects infants in developing countries. EPEC forms attaching and effacing (A/E) lesions on the apical surface of the small intestine, leading to diarrhea. The locus of enterocyte effacement (LEE) is both necessary and sufficient for A/E lesion morphogenesis by EPEC.

Transcriptional and posttranscriptional regulation of the locus of enterocyte effacement in Escherichia albertii.

The diarrheic bacterium Escherichia albertii is a recent addition to the attaching and effacing (A/E) morphotype of pathogens. A/E pathogens cause disease by tightly attaching to intestinal cells, destroying their actin-rich microvilli, and triggering re-localization and repolymerization of actin at the bacterial-host interface to form actin-filled membranous protrusions, termed A/E lesions, beneath the adherent bacterium. The locus of enterocyte effacement (LEE) is required for the biogenesis of these lesions.

The Evasive Enemy: Insights into the Virulence and Epidemiology of the Emerging Attaching and Effacing Pathogen .

The diarrheic attaching and effacing (A/E) pathogen was first isolated from infants in Bangladesh in 1991, although the bacterium was initially classified as Subsequent genetic and biochemical interrogation of these isolates raised concerns about their initial taxonomic placement. It was not until 2003 that these isolates were reassigned to the novel taxon because they were genetically more closely related to , although they had diverged sufficiently to warrant a novel species name. Unfortunately, new isolates continue to be mistyped as enteropathogenic (EPEC) or enterohemorrhagic (EHEC) owing to shared traits, most notably the ability to form A/E lesions.