Trauma Sternotomy Closure: Drain Size May Matter.

BackgroundSternotomy for trauma (ST) can be life-saving, but optimal chest closure techniques and their impact on outcomes remain unclear. This study examines the association between mediastinal drain size used during ST closure and patient outcomes to determine if larger bore drain placement may mitigate need for reintervention after definitive chest closure.MethodsA retrospective review (2015-2023) of all ST patients at an ACS-verified Level 1 trauma center was conducted, excluding intraoperative deaths.

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation.

Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment with the chemical agonist Yoda1 is sufficient to increase cerebrospinal fluid (CSF) outflow by improving lymphatic absorption and transport. The abnormal accumulation of CSF, which often leads to hydrocephalus and ventriculomegaly, currently lacks effective treatments.

Resuscitative Thoracotomy for Traumatic Cardiac Arrest: Potential Impact of Resource Constraint on Outcomes and Blood Product Utilization.

Introduction: Resuscitative thoracotomy (RT) in the setting of traumatic arrest serves as a vital but resource-intensive intervention. The COVID-19 pandemic has created critical shortages, sharpening the focus on efficient resource utilization. This study aims to compare RT performance and blood product utilization before and after the onset of the COVID-19 pandemic for patients in traumatic cardiac arrest.

Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion.

Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1) cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI calcium release-activated calcium modulator 1)-mediated mechanotransduction pathway that triggers lymphatic sprouting through Notch downregulation in response to fluid flow. However, the identity of its upstream mechanosensor remains unknown.

Telemedicine Experience of General Surgery Trainees: Impact on Patient Care and Education.

Objective: The COVID-19 pandemic has had a significant impact on patient care, including the increased utilization of contact-free clinic visits using telemedicine. We looked to assess current utilization of, experience with, and opinions regarding telemedicine by general surgery residents at an academic university-based surgical training program.

Design: A response-anonymous 19-question survey was electronically distributed to all general surgery residents at a single academic university-based general surgery residency program.