Publications by authors named "Brandon D Metcalf"

In recent years, social media (SoMe) has revolutionized medical education within the field of pathology; however, its performance in cytopathology has not been explored in detail. This systematic review aims to analyze SoMe trends, hashtag metrics, and online resources within cytopathology over the period of 7 years. A systematic review of 4 databases (PubMed, Medline, Embase, and Scopus) was conducted between January 1st, 2017, and December 22nd, 2022, in order to identify relevant English-language articles about SoMe and cytopathology.

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Objective: Immuno-checkpoint inhibitors (CPIs) such as PD-1/PD-L1 inhibitors have shown positive effects in treating various metastatic carcinomas but can cause complications like kidney dysfunction. This study aimed to determine if T lymphocytes were the dominant inflammatory cells in CPI-associated acute interstitial nephritis (AIN), graded using a modified Banff criteria for renal transplant cellular rejection.

Methods: 20 renal biopsies from 18 patients with acute kidney injury following CPI treatment for metastatic carcinomas were evaluated.

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Context: IgM-dominant immune complex-mediated glomerulonephritis (IgM-dominant ICMGN) is a rare renal entity, characterized by a membranoproliferative pattern by light microscopy, dominant IgM staining by immunofluorescent staining, and subendothelial deposits by electron microscopy. This study was to investigate if some of IgM-ICMGN were associated with autoimmune disorders induced by hydralazine.

Design: Seven IgM-dominant ICMGN cases were identified over 8 years.

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Article Synopsis
  • The etiology of minimal change disease (MCD) is unclear, but it is characterized by the effacement of foot processes visible through electron microscopy (EM) and the presence of autoimmune IgG antibodies against nephrin.
  • A study identified seven MCD patients with punctate IgG staining outside glomerular capillaries, suggesting a link to ballooning clusters (BBC) of reactive foot processes found in EM images.
  • Immunogold labeling confirmed the presence of IgG within the BBC structures in MCD cases, indicating a possible relationship between these structural changes and the observed IgG staining.
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Context.—: Monoclonal gammopathy of renal significance (MGRS) is a relatively new concept for patients with renal monoclonal protein deposition (RMPD) (except monoclonal cast nephropathy) and has been used as a reason for nephrologists to obtain a bone marrow biopsy (BMB). It takes a team of pathologists and clinicians to determine when RMPD at our institution can be defined as MGRS.

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