Publications by authors named "Bjoern Tampe"
Article Synopsis
- The study focuses on the role of MHC class II, specifically HLA-DR expression in monocytes, in managing immune responses in COVID-19 patients, highlighting its link to secondary infections in severe cases.
- A case of a 61-year-old man with COVID-19 and acute respiratory distress syndrome received a single injection of Interferon-y (IFNy), which resulted in a significant increase in monocyte HLA-DR expression from 26.7% to 83.1%.
- The findings suggest that low mHLA-DR levels are indicative of severe illness and secondary infections, showing that IFNy could be a potential treatment for improving immune response in severely ill COVID-19 patients.
The increasing number of patients with end stage chronic kidney disease not only calls for novel therapeutics but also for pioneering research using convincing preclinical disease models and innovative analytical techniques. The aim of this study was to introduce a virtual histology approach using micro computed tomography (µCT) for the entire murine kidney in order to close the gap between single slice planar histology and a 3D high resolution dataset. An ex vivo staining protocol based on phosphotungstic acid diffusion was adapted to enhance renal soft tissue x-ray attenuation.
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