Hemoglobin response to iron-folic acid supplementation and associated factors among anemic pregnant women attending the University of Gondar Comprehensive Specialized Hospital ANC ward Northwest, Ethiopia 2023: A longitudinal follow up study.

Background: Anemia is the most frequent complication during pregnancy. Iron and folate deficiencies are the primary causes of anemia during pregnancy resulting from low hemoglobin concentration. Globally, preventive strategies such as iron and folic acid supplementation, improved dietary practice and deworming program play a crucial role in reducing the rate of anemia.

The role of advanced diagnostics on precision medicine in hemato oncology.

Advanced diagnostic technologies are driving precision medicine to revolutionize the field of hemato-oncology, that enable personalized treatments based on detailed molecular and genetic profiles. Innovations like next-generation sequencing, digital PCR, and liquid biopsies have reshaped diagnosis, classification, and treatment decisions in hematologic cancers such as leukemia, lymphoma, and myeloma. Each technology offers unique strengths NGS provides broad mutational insights, digital PCR enables ultra-sensitive measurable residual disease detection, and flow cytometry delivers rapid, accessible analysis while also facing specific limitations.

Coagulation profiles and platelet parameters among preeclampsia, eclampsia, and normotensive pregnant women attending Comprehensive Specialized Hospital maternity wards, Northwest Ethiopia.

Background: Hypertensive disorders of pregnancy affect about 10% of all pregnant women worldwide. A variety of hematological abnormalities may occur in women with pregnancy-induced hypertension. Thus, we aimed to compare coagulation profiles and platelet parameters among preeclampsia, eclampsia, and normotensive pregnant women in Northwest Ethiopia.

Bacterial profile and antimicrobial susceptibility pattern of urinary tract infection among diabetic patients at Bule Hora University Teaching Hospital, Southern Ethiopia.

Urinary tract infections (UTIs) are among the most common infectious diseases in both hospital and community settings, leading to increased morbidity and mortality, particularly in patients with DM due to impaired immune function and hyperglycemia. The rise of antimicrobial resistance (AMR) further complicates the treatment of bacterial uropathogens, presenting a significant public health challenge. Thus, this study aimed to assess the magnitude, antimicrobial resistance patterns, and risk factors of bacterial UTIs in DM patients at Bule Hora University Teaching Hospital, Southern Ethiopia, 2023.

Qualitative and Quantitative Blood Cell Disorders Among High-Level Antiretroviral Therapy-Experienced Children in Northwest Ethiopia: A Cross-Sectional Study.

Background And Aims: The human immunodeficiency virus (HIV) and its treatment are commonly associated with blood cell morphological and numerical abnormalities. As a result, routine examination of blood disorders among HIV patients is necessary to minimize related complications and improve patients' prognosis. Therefore, the aim of the current study is also to assess quantitative and qualitative blood cell disorders among high-level antiretroviral therapy (HAART)-experienced children.

The dual effect of interferon-γ in acute myeloid leukemia: A narrative review.

Acute myeloid leukemia (AML) is a hematological malignancy representing a very rapid, uncontrolled growth of myeloid precursors in the BM and peripheral circulation. Studies on AML have highlighted the crucial role of IFN-γ therapy in immune surveillance, both promotive and inhibitory effects on leukemic cells, and regulation of the tumor microenvironment. However, there is a need for a comprehensive understanding of the dual effects of IFN-γ in AML.

Diagnostic accuracy of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in differentiating thyroid tumors: A systematic review and meta-analysis.

Background: Thyroid neoplasms include a range of lesions, most of which are benign, though some may progress to or present as malignant. Diagnostic tools like FNAB, ultrasound, and hormone analysis are commonly used, though they have limitations. Recently, peripheral blood markers have been explored for their potential in differentiating thyroid lesions, despite controversy evidence.

Hematological reference intervals for adult population of Debre Berhan town, North East Ethiopia.

Accurate hematological reference intervals are critical for proper disease diagnosis and patient management. However, many Ethiopian laboratories rely on reference intervals derived from Western populations, which may not reflect the genetic, environmental, and lifestyle factors of the local population. This study aimed to establish locally derived hematological reference intervals for adults in Debre Berhan town, North East Ethiopia.

Effect of radioactive iodine therapy on hematological parameters in patients with thyroid cancer: systematic review and meta-analysis.

Background: Patients with thyroid cancer (TC) are commonly treated with radioactive iodine therapy (RIA) to prevent neoplastic transformation and the re-emergence of cancer cells. However, it has major side effects on blood cells. However, the degree of change in hematological parameters reported varies across studies.

Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia.

Background: Blood biomarkers offers an independent insight for the pathophysiology of hyperbilirubinemia. However, they are not practically used for the differential diagnosis of the hyperbilirubinemia severity. Therefore, the current study aimed to assess the differential diagnostic value of peripheral blood biomarkers with disease severity as an alternative.

External quality assessment in African clinical laboratories: A systematic review and meta-analysis.

Objectives: External quality assessment (EQA) helps evaluate and improve the quality of laboratory testing by providing unbiased reviews. The study aimed to synthesize pooled EQA performance of clinical laboratories across the African region.

Methods: The review was registered in PROSPERO (CRD42024562987) and reported based on the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist.

Global prevalence of anemia in displaced and refugee children: A comprehensive systematic review and meta-analysis.

Background: Anemia due to living condition disproportionally affects the global refugee children. Nutritional deficiency particularly iron deficiency is the primary causes of anemia. Hence, we conducted a systemic review and meta-analysis on the prevalence of anemia among refugee children.

Hematological changes in women with cervical cancer before and after cancer treatment: retrospective cohort study.

Hematological changes is one of the most common complications occurred in cancer patients. Therefore, the current study aimed to assess the hematological toxicity of cervical cancer patients before and after the initiation of treatment. The retrospective cohort study was conducted from 2015 to 2022 at the University of Gondar Comprehensive Specialized Hospital.

Prevalence of potential drug‒drug interactions and associated factors among elderly patients in Ethiopia: a systematic review and meta-analysis.

Background: The occurrence of potential drug‒drug interactions (pDDIs) is a serious global issue that affects all age groups, with the elderly population being the most vulnerable. This is due to their relatively high rates of comorbidity and polypharmacy, as well as physiological changes that can increase the potential for DDIs and the likelihood of adverse drug reactions. The aim of this study was to estimate the prevalence of pDDIs and associated factors among elderly patients in Ethiopia.

Improving laboratory turnaround times in clinical settings: A systematic review of the impact of lean methodology application.

Background: Lean methodology, originally developed in the manufacturing sector, is a process management philosophy focused on maximizing value by eliminating waste. Its application in laboratory settings, particularly concerning laboratory turnaround times (TAT), involves a systematic approach to identifying inefficiencies and optimizing processes to enhance value for end customers.

Methods: This systematic review was registered in PROSPERO with identification number (CRD42024552350) and reported based on the 2020 PRISMA checklist.

Hematological abnormality and associated factors in newborns with hyperbilirubinemia before and after phototherapy at University of Gondar Comprehensive Specialized Hospital.

This study aimed to assess the magnitude of hematological toxicity and associated factors in newborns with hyperbilirubinemia. A cross-sectional study was conducted from April to December 2023. A total of 247 newborns were included.

Performances and determinants of proficiency testing in clinical laboratory services at comprehensive specialized hospitals, northwest Ethiopia.

Proficiency testing (PT) is an impartial laboratory performance-evaluating system using an independent body. It is a mandatory accreditation requirement and means for improving the laboratory's performance. The study aimed to evaluate the performance of PT, with a focus on identifying and discussing determinants that influence PT performance at comprehensive specialized hospitals in northwest Ethiopia.

Navigating Quality Assessment Hurdles in Clinical Laboratory Services: A Comprehensive Review in Resource-Limited Settings.

External quality assessment is the process of evaluating the performance of a laboratory and the competence of professionals. Participation in EQA and standardizing the quality of laboratory services are a mandatory requirements for accreditation. This review is aimed at identifying and discussing challenges that hinder the effective implementation of an EQA program in countries with resource limited setting.

Assessment of hematology laboratory performance in the total testing process using quality indicators and sigma metrics in the northwest of Ethiopia: A cross-sectional study.

Background And Aims: Assuring laboratory quality by minimizing the magnitude of errors is essential. Therefore, this study aimed to assess hematology laboratory performance in the total testing process using quality indicators and sigma metrics.

Methods: A cross-sectional study was conducted from April to June 2022.

Anemia and associated factors among internally displaced children at Debark refugee camp, North Gondar, Northwest Ethiopia.

Background: Children in refugee camps, due to their living conditions, are the most vulnerable groups to suffer from anemia. Nutritional deficiencies, especially iron deficiency is the most common causes of anemia. However, there is limited information on the prevalence and associated factors of anemia in Ethiopia.