Rare earth composite MOFs materials for energy, environmental and medical applications.

Rare Earth Elements (REEs) are a group of seventeen specialized elements that have shown irreplaceable roles in energy, environment and medical fields due to their unique electronic structures and chemical properties. Rare Earth Composite Metal-Organic Frameworks (RE-MOFs) have become a hotspot for interdisciplinary research as they combine the excellent properties of REEs with the porous properties of MOFs, which have high specific surface area, adjustable pore size, abundant active sites, and multifunctionality. In this paper, we systematically review the progress of the application of RE-MOFs in the fields of energy storage and conversion, pollution control, and biomedicine, analyze the performance optimization strategies and challenges, and look forward to the future development direction.

Advances in the Application of Injectable Thermosensitive Hydrogel Systems for Cancer Therapy.

Systemic administration of anticancer therapeutic agents remains a crucial strategy for clinical cancer therapy. However, poor drug accumulation at tumor sites and severe side effects to normal tissues induced by off-target effects lower their therapeutic efficiency and limit their deep application in clinical settings. How to overcome these issues has continuously raised concerns.

Intratumoral Injection of Norcantharidin-Loaded Poly(D,L-lactide)-b-Poly(ethylene glycol)-b-Poly(D,L-lactide) Thermosensitive Hydrogel for the Treatment of Primary Hepatocellular Carcinoma.

In this study we employed self-designed PDLLA-PEG-PDLLA (PLEL) thermosensitive hydrogel to blend with norcantharidin (NCTD), a hydrophilic chemotherapeutic drug possessing curative effect on primary hepatocellular carcinoma (HCC) and adverse effects, then utilized the composite in HCC interstitial chemotherapy. PLEL copolymer was synthesized by ring-opening polymerization, NCTD-loaded PLEL hydrogel was prepared in a simple and reasonable way. The addition of NCTD had no significant effect on the temperature-dependent rheological properties of PLEL hydrogel.

Synthesis and Application of a Novel Gene Delivery Vector for Non-Small-Cell Lung Cancer Therapy.

Human Wnt inhibitory factor-1 (hWIF-1), as an anti-oncogene, holds great promise for non-small-cell lung cancer (NSCLC) therapy. However, the clinical application of hWIF-1 in cancer therapy is limited by elimination and degradation of free hWIF-1 Therefore, it is necessary to develop safe and effective gene delivery vectors for hWIF-1 delivery . In this paper, we synthesized a novel polyethylenimine (PEI) derivative PEI-SP5-2 (PES) based on branched PEI1800 and NSCLC-targeting peptide SP5-2 to deliver hWIF-1 for NSCLC therapy.

Suberoylanilide hydroxamic acid reversed cognitive and synaptic plasticity impairments induced by sevoflurane exposure in adult mice.

Although it has been shown that sevoflurane exposure could impair the cognitive function, there are few effective treatments to prevent this disorder. Suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylase, plays an important role in hippocampal memory formation, which has been proven to enhance memory. As such, we explored whether SAHA could improve the memory impairment induced by sevoflurane in adult mice.

Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro.

The great potential of oridonin (ORI) for clinical application in cancer therapy is greatly limited due to its poor water-solubility. The purpose of this study was to increase the water solubility of oridonin using monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone) (MPEG-PCL) as drug carrier. The ORI-loaded MPEG-PCL micelles were prepared by thin film hydration method.