Discovery of phenoxazine congeners as novel α-glucosidase inhibitors and identification of their biosynthetic gene cluster from Streptomyces sp. CB00316.

α-Glucosidase is considered an ideal target for the treatment of type 2 diabetes mellitus. Streptomyces species are known to produce a plethora of bioactive metabolites. On the basis of genomic information, the one strain many compounds (OSMAC) strategy and various chromatographic separation techniques, two compounds, bezerramycin A (1) and elloxazinone A (2), were identified from among Streptomyces sp.

Transfusion-transmitted infections in hemophilia patients who underwent surgical treatment: a study from a single center in north China.

Introduction: Transfusion-transmitted infections (TTIs) continue to be a major challenge among hemophilia patients. This study was conducted to investigate the prevalence of TTIs including hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and syphilis in patients with hemophilia who received surgical treatment due to bone or joint lesions in the Department of Orthopedics.

Material And Methods: The present study was conducted from July 1996 to November 2016 in Beijing, China.