Clinical Pharmacology Characterization of the First-In-Class Oncolytic Viral Therapy T-VEC in Adults and Pediatric Subjects.

Oncolytic viruses are an emerging class of immunotherapies for cancer treatment. Talimogene laherparepvec (T-VEC) is a first-in-class oncolytic virus approved globally for advanced melanoma. Herein, we describe the quantitative clinical pharmacology aspects of T-VEC that supported the development of this unique therapy.

Diffuse-charge dynamics across a capacitive interface in a dc electric field.

Cells and cellular organelles are encapsulated by nanometrically thin membranes whose main component is a lipid bilayer. In the presence of electric fields, the ion-impermeable lipid bilayer acts as a capacitor and supports a potential difference across the membrane. We analyze the charging dynamics of a planar membrane separating bulk solutions with different electrolyte concentrations upon the application of an applied uniform dc electric field.

Diffuse-charge dynamics across a capacitive interface in a DC electric field.

Cells and cellular organelles are encapsulated by nanometrically thin membranes whose main component is a lipid bilayer. In the presence of electric fields, the ion-impermeable lipid bilayer acts as a capacitor and supports a potential difference across the membrane. We analyze the charging dynamics of a planar membrane separating bulk solutions with different electrolyte concentrations upon the application of an applied uniform DC electric field.

The lift force on a charged sphere that translates and rotates in an electrolyte.

The distortion of the charge cloud around a uniformly charged, dielectric, rigid sphere that translates and rotates in an unbounded binary, symmetric electrolyte at zero Reynolds number is examined. The zeta potential of the particle ζ is assumed small relative to the thermal voltage scale. It is assumed that the equilibrium structure of the cloud is slightly distorted, which requires that the Péclet numbers characterizing distortion due to particle translation, , and rotation, , are small compared to unity.

Role of Stefan-Maxwell fluxes in the dynamics of concentrated electrolytes.

This theoretical analysis quantifies the effect of coupled ionic fluxes on the charging dynamics of an electrochemical cell. We consider a model cell consisting of a concentrated, binary electrolyte between parallel, blocking electrodes, under a suddenly applied DC voltage. It is assumed that the magnitude of the applied voltage is small compared to the thermal voltage scale, RT/F, where R is the universal gas constant, T is the temperature and F is the Faraday's constant.