Publications by authors named "Bettina Keil"
Background: /Objectives: AGE and their receptors like RAGE and Galectin-3 can activate inflammatory pathways and have been associated with chronic inflammatory diseases. Several studies investigated the role of AGE, Galectin-3 and sRAGE in pancreatic diseases, whereas no comprehensive data for chronic pancreatitis (CP) are available.
Methods: Serum samples from CP patients without an active inflammatory process (85 ACP; 26 NACP patients) and 40 healthy controls were collected.
Article Synopsis
- - Chronic pancreatitis (CP) can be linked to oxidative stress, particularly through the formation of advanced glycation endproducts (AGE) from methylglyoxal, which is regulated by the enzyme Glyoxalase I (GLO1).
- - A study analyzed genetic variants (SNPs) in GLO1 among 223 alcohol-related CP and 218 non-alcohol-related CP patients compared to 328 controls, using a larger cohort of up to 1,441 samples for further confirmation.
- - Results showed that common GLO1 variants were not significantly associated with an increased risk of chronic pancreatitis in either alcoholic or non-alcoholic cases.
Flexible silicone membranes are key components for tunable optical lenses. The elastic operation of the membranes impedes the use of classical layer systems for an antireflective (AR) effect. To overcome this limitation, we equipped optical elastomer membranes with "moth-eye" structures directly in the flexible silicone substrate.
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