Publications by authors named "Beth B Moore"
Plasmacytoid dendritic cells (pDCs) are first responders to tissue injury, where they prime naive T cells. The role of pDCs in physiologic wound repair has been examined, but little is known about pDCs in diabetic wound tissue and their interactions with naive CD4+ T cells. Diabetic wounds are characterized by increased levels of inflammatory IL-17A cytokine, partly due to increased Th17 CD4+ cells.
View Article and Find Full Text PDFToll-like receptors, environmental caging, and lung dysbiosis.
Am J Physiol Lung Cell Mol Physiol
August 2021
Article Synopsis
- Recent studies suggest that lung microbiota influences immune responses in the lungs and that toll-like receptors (TLRs) play a crucial role in maintaining lung health.
- Researchers investigated how the absence of TLRs affects lung microbiota by comparing TLR-deficient mice to wild-type mice and found significant differences in community composition, diversity, and bacterial levels in the lungs.
- The study concluded that TLR signaling is important for shaping the lung microbiota, demonstrating that TLR-deficient mice have distinct microbiota profiles that are relatively stable despite varying environmental conditions.
Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.
Am J Respir Crit Care Med
July 2017
Rationale: Differences in the lung microbial community influence idiopathic pulmonary fibrosis (IPF) progression. Whether the lung microbiome influences IPF host defense remains unknown.
Objectives: To explore the host immune response and microbial interaction in IPF as they relate to progression-free survival (PFS), fibroblast function, and leukocyte phenotypes.