Publications by authors named "Beryl C Zhuang"
Accounting for differences between Infinium MethylationEPIC v2 and v1 in DNA methylation-based tools.
Life Sci Alliance
September 2025
The recently launched Illumina Infinium MethylationEPIC v2.0 (EPICv2), successor of MethylationEPIC v1.0 (EPICv1), retains most of the probes in EPICv1, while expanding coverage of regulatory elements.
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- * The study assesses the effects of prenatal and postnatal stress and depression on DNA methylation in newborns and 12-month-old children using the CHILD cohort, measuring stress and depression at multiple time points.
- * Results showed significant associations between both prenatal and postnatal stress/depression and changes in DNA methylation at specific CpG sites in the newborn's cord blood and in blood from 12-month-old children, suggesting a biological impact of maternal mental health on child development.
Article Synopsis
- The Illumina MethylationEPIC BeadChip microarray platform has two versions (v1.0 and v2.0), which show high correlation overall but varying results at the probe level for tools assessing DNA methylation effects.
- Research using blood samples from different adult age groups found that samples clustered more by the EPIC version used than by other characteristics, indicating significant differences in data outputs between the two versions.
- The study emphasizes the need to consider which EPIC version is used when analyzing data for meta-analyses and longitudinal studies, as these differences can impact findings in epigenome-wide association studies (EWAS).