Publications by authors named "Ben-David Chandra"
Cell Mol Life Sci
August 2024
Article Synopsis
- The morphology of dendritic spines, crucial for neuronal functions, is affected by actin filaments and actin-binding proteins, which influence spine density and structure in brain disorders.
- Research reveals that genetic inactivation of CAP1 and CAP2 impairs spine maturation in hippocampal neurons, highlighting their importance in spine development.
- Overactivation of the protein INF2, which promotes unbranched F-actin, further complicates spine maturation, but inhibiting INF2 can rescue spine defects caused by the absence of CAPs, indicating that CAPs regulate INF2 to facilitate proper spine formation.
