Impact of Antibiotics on the Subgingival Microbiome in Advanced Periodontitis: Secondary Analysis of a Randomized Controlled Trial.

: This study aimed to evaluate longitudinal changes in the subgingival microbiome over 12 months following non-surgical periodontal treatment, with or without adjunctive systemic antibiotics, in patients with stage III/IV periodontitis and peripheral artery disease. : After randomizing patients to full-mouth mechanical debridement with/without adjunctive systemic antibiotics (PT1/PT2 group) or no subgingival debridement (control group), periodontal probing depths were measured, scores for 'periodontal inflamed surface area' (PISA) obtained, and subgingival plaque samples collected at baseline and during the 3-month and 12-month follow-up visits. Next-generation 16S DNA sequencing was used to characterize the microbiota of the samples for alpha/beta diversity and differentially abundant taxa.

Effect of Abutment Material on aMMP-8 Levels in Peri-Implant Sulcular Fluid over 12 Months: A Randomized Controlled Trial.

The long-term success of dental implants can be influenced by the material properties of abutments and their interaction with peri-implant tissues. This study investigates the impact of three abutment materials-titanium (Ti), zirconium oxide (Zr), and polymethylmethacrylate (PMMA)-on the inflammatory response in peri-implant sulcular fluid (PISF), using active-matrix metalloproteinase-8 (aMMP-8) as a biomarker. In this prospective, randomized clinical trial, 30 patients were assigned to Ti, Zr, or PMMA abutment groups.

The influence of prosthetic treatments and implant-supported prostheses on posterior mandibular ridge atrophy: a retrospective cohort study.

Aims: Bone preservation is a requirement for long-term stability of dental prostheses, which is all the more important in the posterior mandible, given the particular challenges these areas pose to prosthetic treatment. The objective was to investigate the implications of different prostheses on the atrophy of posterior alveolar bone after tooth loss.

Materials And Methods: A total of 457 treatment cases were retrieved from the medical documentation and information network.

Patient-reported outcomes of zirconia dental implants: a systematic review and future directions.

Purpose: Zirconia dental implants show excellent biocompatibility and tissue integration, low affinity for plaque, and favorable biomechanical properties. However, these objective measures do not adequately replicate the patient's perception. This systematic review evaluated the evidence on patient-reported outcome (PROs) in zirconia dental implant treatment.

Treatment of Localized Gingival Recession with an Enamel Matrix Protein-Coated Xenogeneic Dermal Matrix: A Randomized Controlled Trial.

This study aims to evaluate the influence of the additional use of enamel matrix derivate (EMD) in the treatment of gingival recession defects using a coronally advanced flap (CAF) and a xenogeneic dermal matrix (XDM) by means of digital and clinical assessment methods. In this prospective randomized controlled study, recession height and area, width and thickness of keratinized gingiva, pocket probing depth, and clinical attachment levels were measured at the baseline and followed up for one year. Fifteen patients ( = 15) with 24 gingival recession defects were treated between 2019 and 2021.

Nuclear imaging to visualize periodontal inflammation: Findings of a randomized controlled trial.

Objective: To investigate non-surgical periodontal therapy by 18F-fluorodeoxyglucose (2-[F]FDG) uptake using positron emission tomography (PET) integrated with computed tomography (CT).

Subjects: Eighty-five patients with peripheral artery disease and severe periodontitis-randomized into three groups receiving therapy with (PT1; n = 29) or without (PT2; n = 28) systemic antibiotics or no treatment (controls: n = 28)-underwent nuclear imaging at baseline and at 3 months.

Results: Clinical inflammation (periodontal inflamed surface area; PISA) did not significantly differ across the groups at baseline (p = 0.

A randomized clinical trial of phycogenic materials for sinus grafting with hydroxyapatite versus biphasic calcium phosphate: 2 years clinical outcomes.

Objectives: To assess in a prospective randomized trial two phycogenic bone substitutes-biphasic calcium phosphate (BCP) versus almost pure hydroxyapatite (HA)-for their volume stability and clinical implications after sinus floor elevation (SFE).

Materials And Methods: Twenty patients requiring lateral-window SFE 6 months prior to implant surgery were randomized to a BCP or HA group. As primary outcome, the grafts were analyzed for volume stability, using four cone-beam computed tomography scans obtained immediately/6/12/24 months after SFE.

Association of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathic changes in limited systemic sclerosis.

Objectives: Pathways contributing to endothelial dysfunction in patients with limited cutaneous systemic sclerosis (lcSSc) are largely unknown. The aim of this study was to investigate potential associations of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathy-related changes in patients with lcSSc and early-stage vasculopathy.

Methods: Amino acids, calciotropic parameters, including 25-hydroxyvitamin D and parathyroid hormone (PTH), and bone turnover parameters, including osteocalcin and N-terminal peptide of procollagen-3 (P3NP), were measured in 38 lcSSc patients and 38 controls.

Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A case-control study.

Objectives: Periodontal disease occurs frequently in patients with limited cutaneous systemic sclerosis (lcSSc) while data about underlying pathways contributing to periodontal changes are scarce. The aim of this study was to evaluate periodontal disease and to investigate its association with endothelial dysfunction and clinical changes in patients with lcSSc.

Methods: In 38 lcSSc patients and 38 controls, periodontal status was evaluated by disease-specific questionnaire, dental examination including bleeding on probing (BOP), pocket depth, and plaque index, and dental panoramic radiograph.

Association of periodontitis and diabetic macular edema in various stages of diabetic retinopathy.

Objectives: Periodontitis and diabetes are known to have a bidirectional relationship. Diabetic macular edema is a complication of diabetes that is strongly influenced by inflammatory pathways. However, it remains to be established whether inflammation at other locations, such as periodontitis, affects diabetic macular edema.

In Vitro Study of Surface Changes Induced on Enamel and Cementum by Different Scaling and Polishing Techniques.

Purpose: To determine how the currently available techniques of scaling and root planing, used either alone or with additional polishing techniques, affect the substance thickness and surface roughness of enamel and cementum.

Materials And Methods: After extraction, impacted third molars were prepared and subjected to air polishing with a nonabrasive powder, ultrasonic scaling, or hand instrumentation. All three techniques were performed alone and in combinations for a total of 9 treatment groups.

Periodontal treatment and vascular inflammation in patients with advanced peripheral arterial disease: A randomized controlled trial.

Background And Aims: Observational studies support an association between periodontitis and cardiovascular diseases. The study objective was to assess vascular inflammation after periodontal treatment in patients with peripheral arterial disease.

Methods: Ninety patients with peripheral arterial disease (PAD) and severe periodontitis were enrolled in a randomized, controlled trial.

Dietary intake in patients with peripheral arterial disease and concomitant periodontal disease.

Nutrition plays a crucial role in the pathophysiology and management of peripheral arterial disease (PAD) and periodontal disease (PD). As PD can have profound effects on an individual's functional ability to eat and can affect nutrient intake, we aimed to evaluate the role of PD severity on dietary intake (DI) and quality in PAD patients and compare it with current dietary recommendations for CVD. PD stages of 421 consecutive PAD patients were determined according to a standardised basic periodontal examination (Periodontal Screening and Recording Index) ('healthy', 'gingivitis', 'moderate periodontitis' and 'severe periodontitis').