Health and Wellness Coaching to Reduce Care Burden in ADPKD: A Mixed-Methods Pilot Study of BeWell360-PKD Dyadic Model.

Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) imposes substantial care burden on patients and their informal caregivers (CGs), often contributing to nonadherence and impaired quality of life. Existing care models insufficiently address the behavioral and psychosocial dimensions of this burden. To evaluate the feasibility and impact of BeWell360-PKD , a person-centered intervention integrating Health and Wellness Coaching (HWC) and capacity-workload support into ADPKD care, on care burden, adherence, self-efficacy, activation, and resilience.

Characterizing the ADPKD- Phenotypic Signature With Deep Learning and Advanced Imaging Biomarkers.

Introduction: ADPKD is the third most common disease-causing variant in autosomal dominant polycystic kidney disease (ADPKD) after ADPKD- and ADPKD-. This study aimed to characterize the clinical presentation, progression, and distinctive imaging phenotype of ADPKD-

Methods: This retrospective cohort study included patients with disease-causing variants in , nontruncating (), or . Patients were matched by sex (48.

Rapid Atomic Structure Prediction of Multimetallic Nanoparticles with Physics-Based Machine Learning.

Metal nanoparticles (NPs) find tremendous application in various fields, including catalysis, biomedicine, and electronics, due to their unique physicochemical properties arising from their morphology (i.e., size and shape) and composition.

Multicenter Insights into Peritoneal Dialysis for ADPKD: Role of Cumulative Cystic Organ Volumes in Treatment Complications.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder and the fourth leading cause of kidney failure (KF). Peritoneal dialysis (PD). Preferred for its home-based convenience and cost-effectiveness, is often underutilized in ADPKD due to concerns over enlarged kidneys and heightened complications risks.

Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: A Practical Approach to Screening and Management.

Autosomal dominant polycystic kidney disease (ADPKD), the most prevalent genetic kidney disorder, is characterized by diffuse kidney cysts, hypertension, and progressive kidney function decline, often leading to kidney failure by the age of 60 years. Compared with the general population, patients with ADPKD have an increased risk for development of saccular intracranial aneurysms (IAs), which can lead to intracranial bleeding and result in significant disability and mortality. Of both modifiable and nonmodifiable risk factors, the most significant is a family history of IAs or aneurysm rupture.

Percutaneous Nephrostomy in Kidney Transplant Recipients: Incidence, Risk Factors, Complications and Outcomes.

Ureteral stenosis is a frequent complication after kidney transplantation, causing significant morbidity and potential graft function impairment. Treatment options include conservative management, endourological procedures, surgical interventions and percutaneous nephrostomy (PCN). While PCN effectively relieves obstruction, it comes with its own complications.

Biomarkers of Kidney Disease Progression in ADPKD.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disorder and the fourth leading cause of kidney failure (KF) in adults. Characterized by a reduction in glomerular filtration rate (GFR) and increased kidney size, ADPKD exhibits significant variability in progression, highlighting the urgent need for reliable and predictive biomarkers to optimize management and treatment approaches. This review explores the roles of diverse biomarkers-including clinical, genetic, molecular, and imaging biomarkers-in evaluating disease progression and customizing treatments for ADPKD.