Publications by authors named "Barsha Deshar"
Rosacea is a chronic inflammatory skin disorder characterized by facial erythema, papules, pustules, and telangiectasia, affecting approximately 5.5% of the global population. Current treatments, primarily topical and oral antibiotics and anti-inflammatories, often show limited efficacy and may cause undesirable side effects, prompting the need for alternative therapies.
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- Atopic dermatitis (AD) is a chronic skin condition that causes itching and inflammation, often treated with corticosteroids like dexamethasone for temporary relief, but not as a cure.
- Researchers explored a new non-invasive treatment called quantum molecular resonance (QMR), which showed promise in reducing AD-like skin lesions in a mouse model, minimizing immune cell infiltration and epidermal thickening.
- Transcriptome analysis identified genes, specifically IL36G and SPRR2B, that's linked to inflammation and skin changes; QMR significantly decreased their expression, suggesting QMR could be a potential new therapy for AD.
Background: Atopic dermatitis (AD) is a complex condition characterized by impaired epithelial barriers and dysregulated immune cells. In this study, we demonstrated Forsythia velutina Nakai extract (FVE) simultaneously inhibits basophils, macrophages, keratinocytes, and T cells that are closely interrelated in AD development.
Methods: We analyzed the effect of FVE on nitric oxide and reactive oxygen species (ROS) production in macrophages, basophil degranulation, T cell activation, and tight junctions in damaged keratinocytes.
The Golgi apparatus modifies and transports secretory and membrane proteins. In some instances, the production of secretory and membrane proteins exceeds the capacity of the Golgi apparatus, including vesicle trafficking and the post-translational modification of macromolecules. These proteins are not modified or delivered appropriately due to insufficiency in the Golgi function.
View Article and Find Full Text PDFColorectal cancer is one of the life-threatening ailments causing high mortality and morbidity worldwide. Despite the innovation in medical genetics, the prognosis for metastatic colorectal cancer in patients remains unsatisfactory. Recently, lichens have attracted the attention of researchers in the search for targets to fight against cancer.
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