Publications by authors named "Bamba Gaye"

Aims: Despite being the most common cardiovascular risk factor, the actual burden of hypertension is poorly characterized in Africa. We meta-analyzed the most extensive pooled data to determine the overall prevalence of hypertension in Africa.

Methods And Results: Following PRISMA guidelines, we systematically searched Google Scholar, PubMed, ScienceDirect, and Web of Science databases to retrieve prevalence studies only on hypertension among Africans published between 2002 and 2023.

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Objective: We aimed to analyse the time trends of cardiometabolic risk factors in Senegal from 1975 to 2021.

Design: Ecological study of publicly available data from the WHO Health Inequality Data Repository.

Setting: Disaggregated datasets from publicly available sources.

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The burden of hypertension is rising rapidly in sub-Saharan Africa (SSA), posing significant health challenges and economic costs that hinder national development. Despite being well-studied in clinical medicine, the detection, treatment, and control of hypertension in SSA remain inadequate. This is due to barriers across the care continuum, including individual-, provider-, and system-level obstacles within the health system.

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Article Synopsis
  • Five risk factors (hypertension, hyperlipidemia, obesity, diabetes, smoking) contribute significantly to global cardiovascular disease burden.
  • A study analyzed data from over 2 million people worldwide to understand how these factors affect lifetime risks and potential life-years free of disease and death.
  • Results revealed that having all risk factors increases cardiovascular disease risk significantly, while addressing hypertension and smoking in middle age can lead to the most additional life-years free of disease and death.
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This proposed scientific statement is focused on providing new insights regarding challenges and opportunities for cardiovascular health (CVH) promotion in Africa. The statement includes an overview of the current state of CVH in Africa, with a particular interest in the cardiometabolic risk factors and their evaluation through metrics. The statement also explains the main principles of primordial prevention, its relevance in reducing noncommunicable disease and the different strategies that have been effective worldwide.

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Background: Whether improvements in cardiovascular health (CVH) in midlife mitigate cardiovascular disease (CVD) risk in patients with diabetes remains underexplored.

Objectives: The aim of the study was to examine the relationships between changes in CVH during midlife and subsequent risks of CVD events and all-cause mortality among individuals with and without diabetes.

Methods: The study utilized data from the Atherosclerosis Risk in Communities Study.

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  • Chronic kidney disease (CKD) is linked to hypertension (HBP), with a significant number of people with HBP remaining undiagnosed, especially in developing countries like Senegal.
  • A study in northern Senegal assessed CKD prevalence among three groups: normotensive, diagnosed hypertension, and undiagnosed hypertension, involving over 2,400 individuals aged 18-80.
  • The findings revealed that 52% had HBP and 17.8% had CKD, with undiagnosed hypertensive patients having a notably high rate of CKD, particularly in older women.
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Heart rate, a measure of the frequency of the cardiac cycle, reflects the health of the cardiovascular system, metabolic rate, and activity of the autonomic nervous system. Whether changes in resting heart rate are related to lifespan has not yet been explored to our best knowledge. In this study, we examined the association between resting heart rate and lifespan using linear regression in the Paris Prospective Study I, the Whitehall I Study, and the Framingham Heart Study.

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Objectives: The Life's Simple 7 score (LS7) promotes cardiovascular health (CVH). Despite this, some with optimal LS7 develop cardiovascular disease (CVD), while others with poor CVH do not, termed the "CVH paradox." This paper explores pathways explaining this paradox.

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Article Synopsis
  • The study examined the link between adherence to French dietary guidelines (PNNS-GS2) and the risk of developing type 2 diabetes (T2D) in a cohort of 71,450 women, with an average age of around 53 years.
  • Results showed that better adherence to these dietary guidelines was associated with a reduced risk of T2D, indicating that diet plays a significant role in diabetes prevention.
  • The research also found that this protective effect was primarily mediated by body weight, with more than half of the relationship explained through body mass index (BMI) and waist-hip ratio (WHR).
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Objectives: The objective of this study was to develop clinical classifiers aiming to identify prevalent ascending aortic dilatation in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV).

Design And Setting: A prospective, single-centre and observational cohort.

Participants: The study involved 543 BAV and 491 TAV patients with aortic valve disease and/or ascending aortic dilatation, excluding those with coronary artery disease, undergoing cardiothoracic surgery at the Karolinska University Hospital (Sweden).

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The African region is experiencing an epidemic of cardiovascular disease with dire consequences of increasing morbidity and mortality. Compared with high-income countries where older populations are most affected, the burden of CVD in Africa is higher in the younger populations, which hampers regional socioeconomic development. Strategies to increase and advance the cardiovascular workforce are urgently needed to help address this problem.

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Objective: American Indians and Alaska Natives (AI/ANs) are an understudied population at high risk for cardiovascular diseases (CVDs); little is known about contextual factors contributing to CVDs in AI/ANs. This study examined the association of Life's Simple 7 (LS7) factors and social determinants of health (SDH) with CVD outcomes in a nationally representative sample of AI/ANs.

Methods: We conducted a cross-sectional study of 8497 AI/ANs using 2017 Behavioural Risk Factor Surveillance Survey data.

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Background: The impact of COVID-19 sanitary measures on the time trends in infectious and chronic disease consultations in Sub-Saharan Africa remains unknown.

Methods: We conducted a cohort study on all emergency medical consultations from January 2016 to July 2020, from SOS Medecins in Dakar, Senegal. The consultation records provided basic demographic information such as age, ethnicity (Senegalese or Caucasian), and sex as well as the principal diagnosis using an ICD-10 classification ("infectious", "chronic", and "other").

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Aims: This study aimed to examine the association between cardiovascular health (CVH) metrics and the risk of heart failure (HF) in a Finnish population.

Methods And Results: We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study comprising men aged 42-60 years at baseline (1984-89) and women aged 53-73 years at baseline (1998-2001). The CVH scores were computed from American Heart Association's CVH metrics for 2385 men and 825 women without a history of HF at baseline.

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Background: Maintaining blood pressure (BP) control over time may contribute to lower risk for cardiovascular disease (CVD) among individuals who are taking antihypertensive medication.

Methods: The Jackson Heart Study (JHS) enrolled 5,306 African-American adults ≥21 years of age and was used to determine the proportion of African Americans that maintain persistent BP control, identify factors associated with persistent BP control, and determine the association of persistent BP control with CVD events. This analysis included 1,604 participants who were taking antihypertensive medication at Visit 1 and had BP data at Visits 1 (2000-2004), 2 (2005-2008), and 3 (2009-2013).

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Background Social isolation, the relative absence of or infrequency of contact with different types of social relationships, and loneliness (perceived isolation) are associated with adverse health outcomes. Objective To review observational and intervention research that examines the impact of social isolation and loneliness on cardiovascular and brain health and discuss proposed mechanisms for observed associations. Methods We conducted a systematic scoping review of available research.

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