A Prospective Observational Study on the Diagnosis and Management of Non-Traumatic Abdominal Emergencies in a Tertiary Care Center.

Background: Non-traumatic abdominal emergencies (NTAEs) represent a diverse group of acute abdominal conditions that arise spontaneously and require prompt evaluation and management. These include common presentations such as acute appendicitis, ureteric colic, and pancreatitis. With the rising prevalence of non-communicable diseases like diabetes and hypertension, the clinical profile and complexity of these emergencies are increasing.

Microfluidic synthesis of iron oxide nanoparticles for highly efficient intracellular delivery in stem cells and cancer cells.

Microfluidic devices offer more accurate fluid flow control and lower reagent use for uniform nanoparticle synthesis than batch synthesis. Here, we propose a microfluidic device that synthesizes uniform iron oxide nanoparticles (IONPs) for highly efficient intracellular delivery. The 3D-printed device was fabricated, comprising two inlets in the T-shaped channel with an inner diameter of 2 mm, followed by a helical mixing channel with a single outlet.

A Comparative Study of Preloading With Ringer's Lactate and Intravenous Ephedrine for the Prevention of Hypotension Due to Propofol During Induction of General Anesthesia.

Background Propofol-induced hypotension during induction of general anesthesia remains a significant clinical concern, especially in healthy individuals. This study aimed to compare the effectiveness of two prophylactic interventions, crystalloid preloading with Ringer's lactate and intravenous ephedrine, in maintaining hemodynamic stability during propofol induction in American Society of Anesthesiologists (ASA) I adult patients. Methods A prospective, interventional comparative study was conducted on 40 ASA I adult patients undergoing elective surgeries under general anesthesia.

Primary Extraosseous Ewing Sarcoma of the Vulva: Unravelling the Mystery of a Common Tumor in an Uncommon Site.

Primary vulvar Ewing sarcoma (ES) is exceedingly rare, particularly in postmenopausal women. To date, only 14 cases have been confirmed through molecular cytogenetic analysis. We report the case of a 55-year-old woman presenting with a painful, ulcerated vulvar mass.

Oxygen deficient MoO nanoparticles as peroxidase substitutes, their substrate-nanozyme interactions and real time validation in human serum sample.

Oxygen deficient molybdenum oxide nanosheet (Od-MO Nshs) was synthesised by hydrothermal method and its peroxidase-like activity was established with 3,3',5,5'-Tetramethylbenzidine-(TMB) and o-phenylenediamine dihydrochloride-(OPD) as a co-substrate in presence of Hydrogen peroxide (HO) and catalytic parameters were compared with horseradish peroxidase-(HRP) enzyme. Optimization was carried out for physical and chemical parameters. Synthesised nanoparticles-(NPs) were characterized for size, shape, composition oxidation state etc.