Comparison of Stand-alone Cage versus Intervertebral Cage with Pedicle Screw and Rod Fixation in Dogs with Degenerative Lumbosacral Stenosis.

The aim of this study was to assess the clinical outcome of treatment of degenerative lumbosacral stenosis in dogs with a stand-alone intervertebral spacer (S group) and combined with a pedicle screw and rod fixation (S + PSRF group) in the lumbosacral junction.Retrospective study. Medical records (2014-2023) were reviewed for dogs treated with a stand-alone intervertebral spacer (S group) or a spacer combined with PSRF (S + PSRF group).

Digitally Designed Bone; A 3D-patient-specific Allograft Shelf for Severe Adolescent Hip Dysplasia: From Digital Design to Clinical Reality-A Conceptual Case Report.

Background: Adolescents with severe dysplasia of the hip regularly undergo a periacetabular osteotomy to prevent pain and early osteoarthritis. Unfortunately, this procedure is not suited for severe dysplasia with a non-congruent-deformed hip joint. The optimal treatment might be a tailor-made biologic optimization of femoral coverage with a shape matching the aberrant anatomy.

In vitro and in vivo delivery of mRNA to joint cells using polymeric nanoparticles.

Osteoarthritis (OA) is a progressive and degenerative disease of the joints, characterized by inflammation and loss of cartilage. Recently, mRNA therapies have emerged as promising disease-modifying treatments for cartilage repair and regeneration. Poly(amidoamine)-based polymeric nanoparticles (PAA-based NPs) were previously developed for intracellular mRNA delivery in chondrocytes, showing high biocompatibility and transfection efficiency.