Statistical Analysis Plan for a Randomized Controlled Trial of Intensive Blood Pressure Control on Cardiovascular risk Reduction in Patients with Atrial Fibrillation.

Introduction: Elevated blood pressure (BP) is a key modifiable risk factor for cardiovascular (CV) complications in patients with atrial fibrillation (AF). While current guidelines recommend modest BP targets, the optimal target in AF patients remains uncertain. The Cardiovascular Risk Reduction in Atrial Fibrillation Trial (CRAFT) is a multicenter, prospective, randomized, open-label, blinded-endpoint trial that evaluates whether intensive home systolic BP control (<120 mmHg) is superior to standard BP control (<135 mmHg) in reducing major CV events.

Evaluation of Population-Based Sodium Reduction Strategies in China: Protocol for a Study Using a Combined Quantitative and Qualitative Approach.

Sodium intake in China is among the highest in the world, particularly in rural areas. A government-led national sodium reduction program has been implemented but evaluations of its implementation and effectiveness remain limited. The study will use a combined qualitative and quantitative approach and a before-after design, to monitor and evaluate the implementation and effectiveness of the sodium reduction program in the rural areas of four provinces geographically distributed throughout China: Heilongjiang, Shanxi, Guizhou, and Guangdong.

Stakeholder perspectives on scaling up potassium-enriched salt to reduce cardiovascular disease in Australia: a qualitative study.

Background: Cardiovascular disease, the world's leading cause of death, could be significantly reduced through sodium reduction strategies; however, the implementation of such strategies has had limited impact in Australia and globally. Switching to potassium-enriched salt is a highly promising intervention, but uptake by the food industry and consumers remains limited. This study investigated the barriers and enablers for scaling up potassium-enriched salt use in Australia.