Exposure to Lead and Incidence of Alzheimer Disease and All-Cause Dementia in the United States.

Introduction: Growing evidence suggests lead exposure may increase dementia risk, but evidence from human studies is limited. We investigated associations between lead exposure and incident Alzheimer disease (AD) and all-cause dementia in a nationally-representative, prospective cohort.

Methods: We examined over 14,000 individuals with baseline measured blood lead and estimated patella and tibia lead from the National Health and Nutrition Examination Survey (NHANES)-III (1988-1994) and continuous NHANES (1999-2016), linked to Medicare and the National Death Index for incident AD and all-cause dementia, with up to 30 years of follow-up.

Bioengineered Chip Model for Magnetic-Nanoparticle-Driven Targeted Cancer Therapy.

Magnetic drug targeting (MDT) leverages external magnetic fields to guide magnetic drug carriers (MDCs) to diseased sites. However, its clinical use is hindered by challenges such as the weakening of magnetic fields with tissue depth, MDC size/instability issues, and hydrodynamic shear. Despite years of research, progress remains limited due to the absence of reliable disease models, as animal models pose ethical and interspecies concerns, while current synthetic platforms struggle to replicate the tumor microenvironment (TME) and assess cellular responses to magnetic stimuli accurately.

Ag-decorated 2D CuO nanoflakes: a dual-functional material for solar-driven photocatalysis and antimicrobial applications.

Developing effective strategies to reduce and prevent water pollution due to excessive contamination by harmful pollutants is crucial. Consequently, there is a requirement to design new catalyst materials to enhance the efficiency of the oxidation processes for the wastewater management plant, ensuring the mineralization of trace organic pollutants. Here, we wisely modified the surfaces along with the morphology of copper oxide (CuO) nanostructures with silver (Ag) nanoparticles (~12-20 nm), a variety of Ag-decorated (~7-16%) CuO two-dimensional (2D) nanoflakes (length ~400 nm and width ~70 nm) with enhanced photocatalytic and antibacterial properties, that can provide sustainable solutions to present environmental remediation.

The role of financial stress, food insecurity, and COVID-19-related illness concerns shaping mental health in five South Asian countries during the pandemic (2020-2022): A secondary analysis of the online COVID-19 Trends and Impact Survey (CTIS) data.

The COVID-19 pandemic has substantially impacted mental health worldwide, yet little attention has been given to its acute and long-term effects on mental health in low- and middle-income countries (LMICs). This study investigates how a triad of pandemic-related worries-financial stress, food insecurity, and COVID-19-related illness concerns-are associated with depression and anxiety across five South Asian LMICs: Bangladesh, India, Nepal, Pakistan, and Sri Lanka. Using data from the COVID-19 Trends and Impact Survey (CTIS), we analyzed responses from over 3.