Highly Branched Sulfated Glycopolymers as Mucin Mimetics.

Mucins are highly complex glycoproteins that form protective and lubricating barriers around epithelial surfaces, e.g., in the respiratory tract, to protect against pathogens.

Orthogonal and Multiresponsive Quinolinone Systems for Reversible and Recyclable Polymer Networks.

Achieving precise control over covalent bond formation and cleavage is critical for advancing material recycling and enabling repeated reuse. Here, we introduce quinolinones as versatile, multistimuli-responsive motifs enabling orthogonal and controlled covalent bond manipulation via a reversible [2π + 2π] cycloaddition triggered by light and thermal stimuli. While photochemical bond formation is well-established, thermal reversion of such bonds for material deconstruction remains underexplored.

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Unlabelled: Surface performance is critically influenced by topography in virtually all real-world applications. The current standard practice is to describe topography using one of a few industry-standard parameters. The most commonly reported number is a, the average absolute deviation of the height from the mean line (at some, not necessarily known or specified, lateral length scale).

PTCH1::GLI1 Fusion Tumors of the Ovary: A Clinicopathologic Study of 3 Cases.

GLI1-altered tumors of the gynecologic tract are extremely rare. We report 3 cases of ovarian PTCH1::GLI1 fusion tumor in patients ranging from 54 to 58 yrs of age, who presented with unilateral FIGO stage I tumors. The tumors ranged from 12 to 20 cm and consisted of uniform epithelioid cells with eosinophilic/clear cytoplasm, arranged in nests and trabeculae surrounded by delicate vessels.

An Unusual Presentation of Bullous Skin Lesions During Pregnancy.

Here, we present a 33-years-old pregnant female who at 27-weeks gestation developed an unusual rash on her left knee after a spider bite. The rash rapidly became systemic requiring admission and treatment with high-dose steroids. Patient rapidly developed complications of steroid therapy and saw no benefits in reducing the activity of the rash of symptoms of itching.