Publications by authors named "B Mignot"
Article Synopsis
- - This study aimed to analyze the final height (FH) trends in French patients with X-linked hypophosphatemia (XLH) over the past decades, as there was limited data on FH's natural history in this condition.
- - Researchers conducted a retrospective study involving 398 XLH patients, dividing them into three birth groups (1950-1974, 1975-2000, and 2001-2006) to compare their average final heights.
- - Results showed a significant increase in mean FH over the generations, with men still being shorter than women, indicating ongoing challenges in treating XLH. Despite improvements, many patients continue to have short stature, highlighting the need for continued progress.
Growth hormone treatment improves final height in children with X-linked hypophosphatemia.
Orphanet J Rare Dis
December 2022
Article Synopsis
- - Despite conventional treatments, 40-50% of children with X-linked hypophosphatemia (XLH) still experience growth failure, prompting a study on the role of rhGH (recombinant human growth hormone) in improving their final height.
- - A study analyzed two groups of children, one treated with rhGH and the other not, finding that rhGH significantly increased height measurements after 2 years, but final height was similar in both groups.
- - The research concludes that rhGH can enhance final height in children with XLH and suggests it as a potential treatment option for those experiencing growth issues.
Introduction: Vitamin D-dependent rickets type 1A (VDDR1A) is a rare genetic disease associated with loss-of-function variations in the gene encoding the vitamin D-activating enzyme 1α-hydroxylase (CYP27B1). Phenotype-genotype correlation is unclear. Long-term outcome data are lacking.
View Article and Find Full Text PDFCharacteristics of adolescents with chronic poorly controlled type 1 diabetes - A qualitative study.
Arch Pediatr
November 2022
Aims: During adolescence, a minority of adolescents with type 1 diabetes have persistent and serious poor metabolic control. The main cause of poorly controlled diabetes during adolescence seems to be poor adherence to therapy. The reasons are intertwined between social, family, psychological, and other factors.
View Article and Find Full Text PDFPulmonary infections caused by (PA) represent the leading cause of pulmonary morbidity in adults with cystic fibrosis (CF). In addition to tobramycin, colistin, and aztreonam, levofloxacin has been approved in Europe to treat PA infections. Nevertheless, no lung deposition data on inhaled levofloxacin are yet available.
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