Unraveling Cross-Cellular Communication in Sex Determination: A Network Ontology Transcript Annotation (Nota) Analysis.

L. (marijuana, hemp) is a dioecious angiosperm species currently evolving sex chromosomes. Genetic mechanisms, primarily controlled by an XY chromosome system, appear to dictate sex expression in .

Locomotor activity depends on β-arrestin recruitment by the dopamine D receptor in the striatal D-D receptor heteromer.

Several dopaminergic compounds, including the clinically used pramipexole, are labelled as preferential dopamine D receptor (DR) agonists based on their moderately higher affinity for the DR versus other D-like receptor subtypes. In rodents, these compounds typically produce locomotor depression with low doses and locomotor activation with higher doses, which has been assumed to be mediated by presynaptic DRs and postsynaptic striatal DRs, respectively. However, studies with selective pharmacological and genetic blockade of each dopamine receptor subtype suggest opposite roles.

Assessing fall risk in multiple sclerosis using patient-reported outcomes and wearable gait metrics.

Background: Falls in people with multiple sclerosis (pwMS) lead to morbidity and expense.

Objective: Identify clinical metrics associated with falls.

Methods: Eighty-six pwMS completed fall surveys, timed 25-foot walk (T25FW), and motion analysis with Clario Opal devices.

ESG-1-60 and ESG-1-61: Novel dopamine D receptor-preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents.

Background And Purpose: Preclinical studies suggest that highly selective dopamine D receptor (DR) antagonists or partial agonists hold promise for treating substance use disorders. However, their limited effectiveness in reducing cocaine self-administration is a major drawback. This study investigated whether cariprazine (D receptor-preferring partial agonist) and its analogues ESG-1-60 and ESG-1-61 have enhanced efficacy in reducing cocaine-taking and cocaine-seeking behaviour.