Anti-lipidemic and anti-diabetic properties of saponins: an in-silico approach.

Unlabelled: Diabetes mellitus and dyslipidemia make a significant contribution to mortality and morbidity. The saponins have a variety of pharmacological effects, including the possibility of lowering diabetes and cholesterol levels. In the present study, molecular docking and molecular dynamic simulations were used in silico in order to understand the protein league stability and molecular interactions by aiming at anti-diabetic and anti-lipidemic proteins.

Utilization of Phenylpropanoids by Newly Isolated Bacterium Pseudomonas sp. TRMK1.

A bacterium Pseudomonas sp. TRMK1 capable of utilizing various phenylpropanoids was isolated from agro-industrial waste by enrichment culture technique. It is gram-negative, motile, aerobic, and able to utilize three different phenolic acids such as p-coumaric, ferulic, and caffeic acids at concentrations of 5, 10, and 15 mM in 18 h of incubation.

Influence of DMF-induced oxidative stress on membrane and periplasmic proteins in Paracoccus sp. SKG.

The present study describes the N,N-dimethylformamide (DMF)-induced oxidative stress in Paracoccus sp. SKG. The oxidative stress was evaluated by analysing membrane and periplasmic proteins and K+ efflux, as well as by monitoring the activities of antioxidant enzymes like catalase, superoxide dismutase (SOD) and glutathione S-transferase (GST).

The response of Paracoccus sp. SKG to acetonitrile-induced oxidative stress.

Organic solvents enhance intracellular oxidative stress and induce various physiological responses in bacteria. The study shows the morphological changes in Paracoccus sp. SKG when exposed to higher concentrations of acetonitrile, which alter the composition of the membrane fatty acid that accompanies the increase in K(+) efflux.

Indole-3-acetic acid biosynthesis in Fusarium delphinoides strain GPK, a causal agent of Wilt in Chickpea.

Fusarium delphinoides (Ascomycota; Nectriaceae) is an indole-3-acetic acid (IAA) producing plant pathogen and a causal agent of wilt in chickpea. The IAA biosynthetic pathway in F. delphinoides strain GPK (FDG) was examined by analyzing metabolic intermediates and by feeding experiments.