Disturbances of Dental Development in Cleidocranial Dysplasia.

Objective: This study aimed to investigate the delay in dental development in patients with cleidocranial dysplasia (CCD) applying a longitudinal approach of maturational stages of teeth. A secondary objective was to examine whether an increasing number of supernumerary teeth influences dental development.

Methods: A total of 38 patients were included, consisting of 13 patients with CCD and 25 without CCD, selected from the Generation R Study.

Oral and craniofacial research in the Generation R study: an executive summary.

Objectives: Oral conditions are of high prevalence and chronic character within the general population. Identifying the risk factors and determinants of oral disease is important, not only to reduce the burden of oral diseases, but also to improve (equal access to) oral health care systems, and to develop effective oral health promotion programs. Longitudinal population-based (birth-)cohort studies are very suitable to study risk factors on common oral diseases and have the potential to emphasize the importance of a healthy start for oral health.

Novel Genetic Determinants of Dental Maturation in Children.

Dental occlusion requires harmonious development of teeth, jaws, and other elements of the craniofacial complex, which are regulated by environmental and genetic factors. We performed the first genome-wide association study (GWAS) on dental development (DD) using the Demirjian radiographic method. Radiographic assessments from participants of the Generation R Study (primary study population,  = 2,793; mean age of 9.

Outcomes of dental implants in young patients with congenital versus non-congenital missing teeth.

Objective: This cross-sectional study aims to investigate the effect of the cause of missing teeth on the survival and subjective success of dental implant treatment (DIT) in young patients with missing teeth due to non-congenital causes (tooth loss) in comparison to patients with missing teeth because of congenital causes (hypodontia and oligodontia).

Material And Methods: All patients were asked 7 questions to extract information about the survival and subjective success of DIT. Implant survival function was designed using the Kaplan-Meier analysis.

The association of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development.

Objective: Low folic acid, folate and vitamin B12 might affect tooth formation and mineralization. The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Among 3728 mothers and their 10-year-old children from the Generation R Study, we investigated associations of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development.