Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution.

Overall adiposity and body fat distribution are heritable traits associated with altered risk of cardiometabolic disease and mortality. Performing rare-variant (minor allele frequency <1%) association testing using exome-sequencing data from 402,375 participants of European ancestry in the UK Biobank for nine overall and tissue-specific fat distribution traits, we identified 19 genes where putatively damaging rare variation associated with at least one trait (Bonferroni-adjusted p < 1.58 × 10) and 50 additional genes at false discovery rate (FDR) ≤1% (p ≤ 4.

Market-based instruments to fund nature-based solutions for flood risk management can disproportionately benefit affluent areas.

Market-based instruments, including competitive tenders, are central to funding global environmental restoration and management projects. Recently, tenders have been utilised to fund Nature-based Solutions schemes for Natural Flood Management, with the explicit purpose of achieving co-benefits; flood management reducing inequities. While multiple studies consider the efficacy of Nature-based Solutions for tackling inequities, no prior research has quantified whether the resource allocation for these projects has been conducted equitably.

Lessons learned: Clinicians' perspectives, knowledge and attitudes towards a stroke-integrated cardiac rehabilitation programme.

ObjectiveTo evaluate the perceptions, knowledge, and attitudes of multidisciplinary clinicians within a healthcare organisation completing a stroke-integrated cardiac rehabilitation research programme in addition to usual care neurorehabilitation.DesignA qualitative study based on a phenomenological approach.SettingOne-on-one, semi-structured, qualitative interview completed either face-to-face or over the telephone.

Integrating the 6-Minute Walk Test Into New York Heart Association Functional Classification.

The New York Heart Association (NYHA) Functional Classification System is integral to guiding management of patients with heart failure. However, reproducibility remains a challenge due to subjective assessment of patient functional capacity based on self-reported symptoms and clinical interpretations. The 6-minute walk test (6MWT), involving walking as far as possible in 6 minutes, represents a simple, objective functional assessment tool.

An investigation of improving validity in upper limb measurements for people with tetraplegia using construct specification equations.

The aim of this paper is two-fold: to investigate development of a Construct Specification Equation (CSE) for UL task difficulty, , and a CSE for person UL ability, , in support of the validity of these two constructs. Measurements of UL task difficulty, , and person UL ability, were derived from applying the Rasch model on the Tetraplegia Upper Limb Activity Questionnaire (TUAQ). The formulations of CSEs as explanations of the two constructs were done using Principal Component Regression (PCR).