Genetic Landscape of Congenital Cataracts in a Swiss Cohort: Addressing Diagnostic Oversights in Nance-Horan Syndrome.

Congenital cataracts (CCs) are a leading cause of preventable childhood blindness, with genetic factors playing a crucial role in their etiology. Nance-Horan syndrome (NHS) is a rare X-linked dominant disorder associated with CCs but is often underdiagnosed due to variable expressivity, particularly in female carriers. : This study aimed to explore the genetic landscape of CCs in a Swiss cohort, focusing on two novel and one novel variants and their phenotypic presentation.

Comparison of Intraocular Pressure Measurements with Goldmann Applanation Tonometry, iCare, and Tono-Pen in Young Children with Anterior Segment Abnormalities Under General Anesthesia.

: In young patients with suspected elevated intraocular pressure (IOP), examinations under general anesthesia remain the gold standard. This study aimed to compare the reliability of Goldmann applanation tonometry (Perkins), iCare rebound tonometry, and the Tono-Pen in young children under general anesthesia in a clinical setting. : This retrospective study included patients under six years of age requiring an ophthalmic examination under general anesthesia.

Choice of Corticosteroid Is Associated With the Possibility of Subsequent Surgery for Trigger Finger: A Retrospective Cohort Study.

Introduction: Trigger finger is one of the most common conditions treated by hand surgeons. Although corticosteroid injection is a common first-line treatment, there is no consensus regarding the most effective type of steroid.

Methods: The authors performed a retrospective cohort study of patients with a diagnosis of trigger finger within Kaiser Permanente Northern California, a large, community-based, integrated health system with a comprehensive electronic medical record.

Relationships of Personality Traits With the Taxonomic Composition of the Gut Microbiome Among Psychiatric Inpatients.

Objective: Through the brain-gut-microbiome axis, myriad psychological functions that affect behavior share a dynamic, bidirectional relationship with the intestinal microbiome. Little is known about the relationship between personality-a stable construct that influences social- and health-related behaviors-and the bacterial ecosystem. The authors of this exploratory study examined the relationship between general and maladaptive personality traits and the composition of the gut microbiome.

Individually guided neuromodulation in special operator veterans with symptoms of PTSD and traumatic brain injury: preliminary data from a chart review.

Introduction: Special operations forces (SOF) are at particular risk of suffering from Posttraumatic Stress Disorder (PTSD) and Traumatic Brain Injury (TBI), and often these two conditions are comorbid, with the inciting event causing both conditions. These conditions present with broad-band electroencephalogram (EEG) abnormalities that may be amenable to neuromodulation.

Methods: This retrospective chart review reports on preliminary safety and clinical response data of individualized neuromodulation in a cohort of SOF veterans suffering from symptoms of PTSD and TBI.