Crystal structure and nucleic acid binding activity of the conserved UPF0235 family protein PF1765 from Pyrococcus furiosus.

The UPF0235 UniProt family proteins are conserved across archaea, bacteria, and eukaryotes; however, they remain functionally uncharacterized. Here, we report the high resolution (1.3 Å) crystal structure of UPF0235 protein (PF1765, UniProt: Q8U052) from Pyrococcus furiosus.

Efficacy of a Multimodal Ayurveda Regimen in the Management of Primary Knee Osteoarthritis: Protocol for an Open-Label Randomized Controlled Trial.

Background: Ayurveda recommends a comprehensive therapeutic approach for osteoarthritis management. However, most of the published clinical studies on Ayurveda interventions for osteoarthritis management have addressed selected modalities of Ayurveda treatment rather than the holistic therapeutic regimen.

Objective: This study aimed to assess the efficacy and safety of a multimodal Ayurveda treatment protocol in the long-term management of primary osteoarthritis of the knee compared with standard care.

Prevalence of Human Leukocyte Antigen Alleles Polymorphism in North Indian Population.

Background: Human leukocyte antigens (HLA) are highly polymorphic glycoproteins required for immune response and recognizing self or non-self. Knowing the HLA diversity in a population may be helpful in the selection of organ allocation for transplantation. We aimed to retrospectively analyze the prevalence of HLA, A, B, C, DRB1, and DQA1 alleles frequency in the north Indian population.

Exploring the genetic footprints of the gotra system in the Koṅkaṇī Sārasvata Brahmins.

The gotra system of exogamy is followed by the Brahmin caste group in India. This system restricts the marriage of individuals who belong to the same gotra. In genetic terms, each gotra forms an exogamous group within a population and thereby maintains a lineage.

Device area invariant conductance linearity in scalable silver nanostructure based neuromorphic devices with threshold activation following nociceptive behavior.

Achieving precise control over conductance linearity and low-power switching across different device geometries remains a significant challenge in neuromorphic computing research aiming to mimic efficient in-memory processing. Despite notable advancements, traditional resistive switching elements often face issues such as stochastic switching and non-linear conductance evolution, limiting precision and scalability in neuromorphic applications. This study presents a self-assembled hierarchical Ag nanostructure active material with interdigitated electrode architecture designed to achieve area-invariant conductance linearity and low-voltage threshold switching (∼0.