Biogeochemical and microbial community responses to anthropogenic nutrient inputs into the Solent.

Given their pivotal role in providing essential ecosystem services, understanding the dynamics of coastal waters and their responses to disturbances such as climate change and nutrient pollution is imperative. In this study, we conducted year-long monitoring (May 2021 to May 2022) of the pico- and nanoplanktonic community driving biogeochemical cycling in waters of the Solent on the south coast of the UK. Our investigation revealed that the Solent receives excess nutrient influxes year-round, attributable to sewage spills transported through the intertidal Langstone Harbour, amounting 45.

Chimeric antigen receptor-modified T-cell therapy: Recent updates and challenges in autoimmune diseases.

Chimeric antigen receptor (CAR) T-cell therapy (CAR-T) has revolutionized the treatment of hematologic malignancies, demonstrating significant clinical efficacy and leading to US Food and Drug Administration approval of several CAR T-cell-based products. This success has prompted exploration of CAR-T in other disease areas, including autoimmune diseases (AIDs). CAR-T targeting B cells has been shown to provide clinical and biological improvements in patients with refractory AIDs.

Tiny comets under the sea.

A mucus drag on sinking marine snow may have big biogeochemical implications.

Urinary cytomegalovirus excretion: The unresolved issues.

Cytomegalovirus (CMV) excretion in urine is frequently observed in clinical practice. However, the specific circumstances and pathophysiological mechanisms underlying this shedding remain largely unknown. Here, we address some of the key questions regarding urinary CMV excretion, focusing on new hypotheses raised by recent advances in the field.